Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives.

Alafeefy AM; Kadi AA; Al Deeb OA; El Tahir KE; Al Jaber NA

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Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives.

机译：一些新型喹唑啉衍生物的合成，镇痛和抗炎评价。

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Two series of some new 2,4,6-trisubstituted-quinazoline derivatives were prepared and screened for their analgesic, anti-inflammatory activity and acute toxicity. Four compounds were more potent analgesic agents than the reference drug Indomethacin and thirteen compounds showed significant anti-inflammatory activity. Seven compounds showed combined ability to inhibit both pain and inflammation. Compounds tested for acute toxicity showed no toxic symptoms or mortality rates 24 h post-administration implying their good safety margin.

机译：制备两种新的2,4,6-三取代的喹唑啉衍生物并筛选它们的镇痛，抗炎活性和急性毒性。四种化合物比参考药物吲哚美辛和13种化合物显示出显着的抗炎活性。七种化合物显示出综合抑制疼痛和炎症的能力。测试急性毒性的化合物显示出无毒症状或死亡率24小时后给药暗示其良好的安全保证金。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第11期|共6页
作者
Alafeefy AM; Kadi AA; Al Deeb OA; El Tahir KE; Al Jaber NA;
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Department of Pharmaceutical Chemistry College of Pharmacy King Saud University Riyadh 11451 P.O. Box 2457 Saudi Arabia.;

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正文语种 eng
中图分类药学;
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1. Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives. [J] . Alafeefy AM, Kadi AA, Al Deeb OA, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：某些新型喹唑啉衍生物的合成，镇痛和抗炎评估。
2. Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives. [J] . Alafeefy AM, Kadi AA, Al Deeb OA, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：一些新型喹唑啉衍生物的合成，镇痛和抗炎评价。
3. Synthesis, Anti-inflammatory and Analgesic Synthesis, Anti-inflammatory and Analgesic New 4(3H)-Quinazolinone Derivatives. [J] . Yesilada A, Koyunoglu S, Saygilia N, Archiv der Pharmazie . 2004,第2期

机译：合成，消炎和镇痛剂合成，消炎和镇痛剂新的4（3H）-喹唑啉酮衍生物。
4. Evaluation of the anti-inflammatory and analgesic activities of the total saponins extracted from fermented Polygala japonica HOUTT [C] . Mingxing Liu, Ting Zhu, Shene Guo, International conference on biotechnology, chemical and materials engineering . 2013

机译：发酵远志HOUTT提取总皂苷的消炎镇痛活性评价
5. Design, synthesis and evaluation of some novel substituted quinazolines as antihypertensive and antihistaminic agents. [D] . Alagarsamy, V. 2015

机译：设计，合成和评估一些新型的取代喹唑啉类抗高血压药和抗组胺药。
6. Novel sulindac derivatives: synthesis characterisation evaluation of antioxidant analgesic anti-inflammatory ulcerogenic and COX-2 inhibition activity [O] . Mashooq A. Bhat, Mohamed A. Al-Omar, Nawaf A. Alsaif, 2020

机译：新型舒林酸衍生物：合成表征抗氧化剂止痛剂抗炎剂致溃疡性和COX-2抑制活性的评估
7. Furo(3,2-b)indole derivatives. I. Synthesis and analgesic and anti-inflammatory activities of 4,6-disubstituted-furo(3,2-b)indole-2-carboxamide derivatives. [O] . YOSHIMOTO NAKASHIMA, YUTAKA KAWASHIMA, FUSAO AMANUMA, 1984

机译：呋喃（3,2-B）吲哚衍生物。 I. 4,6-二取代 - 呋喃（3,2-B）吲哚-2-甲酰胺衍生物的合成和镇痛和抗炎活性。

Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives.

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