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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Design, synthesis and in vitro evaluation of antitubercular and antimicrobial activity of some novel pyranopyrimidines.
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Design, synthesis and in vitro evaluation of antitubercular and antimicrobial activity of some novel pyranopyrimidines.

机译：一些新型吡喃嘧啶的抗细胞和抗菌活性的设计，合成和体外评价。

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摘要

The clinical significance of pyran and pyrimidine condensed systems and the raise in problem of multidrug resistant bacterial pathogens has directed us to synthesize pyranopyrimidine derivatives via the reactions of the versatile, 2-amino-4-(4-methoxyphenyl)-4H-substituted chromene-3-carbonitrile with the appropriate reagents. The newly synthesized compounds were characterized by IR, (1)H NMR, (13)C NMR, Mass spectra and Elemental analysis. The compounds were evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H(37)Rv [ATCC-27294] and antibacterial activity against Staphylococcus aureus [ATCC-25923] and Streptococcus pyogenes [MTCC-443] as gram-positive, Escherichia coli [ATCC-25922] and Pseudomonas aeruginosa [MTCC-441] as gram-negative bacterial strains and antifungal activity against Aspergillus niger [MTCC-282]. Several derivatives exhibited pronounced antitubercular and antimicrobial activities.
机译：吡喃和嘧啶浓缩系统的临床意义和多药物抗性细菌病原体问题的提升鉴定了我们通过通用，2-氨基-4-（4-甲氧基苯基）-4H-取代的Chrome烯的反应合成吡喃嘧啶衍生物 3-碳腈，具有适当的试剂。 新合成的化合物的特征在于IR，（1）H NMR，（13）C NMR，质谱和元素分析。 评价化合物的抗细菌性抗细菌性H（37）RV [ATCC-27294]的体外抗细胞活性，以及针对金黄色葡萄球菌的抗菌活性[ATCC-25923]和链球菌化合物[MTCC-443]作为革兰氏阳性的大肠杆菌[ ATCC-25922]和假单胞菌铜绿假单胞菌[MTCC-441]作为革兰氏菌尼格斯尼日尔的革兰氏阴性细菌菌株和抗真菌活性[MTCC-282]。 几种衍生物表现出明显的抗细胞和抗菌活性。

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