Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives.

Manjunatha K; Poojary B; Lobo PL; Fernandes J; Kumari NS

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Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives.

机译：1,3,4-氧代唑衍生物的合成与生物学评价。

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The acid hydrazides (2) derived from ibuprofen and 4-methylthiophenyl acetic acids have been subjected to cyclization with carbon disulphide under basic conditions to yield 1,3,4-oxadiazol-2-thiones (3) which on aminomethylation with formaldehyde and secondary amines afforded a series of Mannich bases (4 and 5). Purity of the compounds has been confirmed by TLC. Structures of these compounds were established on the basis of elemental analyses and spectral studies. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and antimicrobial activities.

机译：在碱性条件下，已经在基本条件下对衍生自布洛芬和4-甲基噻吩基乙酸的酸酰肼（2）在碱性条件下对碳二硫化物环化，以产生1,3,4-恶二唑-2-张（3），其在甲醛和仲胺的氨基甲基化上提供了一系列Mannich Bases（4和5）。通过TLC证实了化合物的纯度。基于元素分析和光谱研究建立这些化合物的结构。评估新合成的化合物，用于其抗炎，镇痛，溃疡性和抗微生物活性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第11期|共9页
作者
Manjunatha K; Poojary B; Lobo PL; Fernandes J; Kumari NS;
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Department of Chemistry Mangalore University Mangalagangothri-574 199 Karnataka India.;

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正文语种 eng
中图分类药学;
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1. Design, synthesis and biological evaluation of 1,3,4-oxadiazole derivatives. [J] . Jha KK, Samad A, Kumar Y, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：1,3,4-恶二唑衍生物的设计，合成和生物学评价。
2. Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives. [J] . Manjunatha K, Poojary B, Lobo PL, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：1,3,4-氧代唑衍生物的合成与生物学评价。
3. Design, synthesis and biological evaluation of 1,3,4-oxadiazole derivatives. [J] . Jha KK, Samad A, Kumar Y, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：1,3,4-氧代唑衍生物的设计，合成及生物学评价。
4. Synthesis, characterization of some new l,3-oxazine-4-one derivatives containing 1,3,4-oxadiazole and 1,3,4-thiadiazole moiety with screening some of their biological activity. [C] . Raneen Hashim Rida, Maysoon Tariq Tawfiq International Scientific Conference on Pure Sciences, Brilliant Creativity and Renewed Building . 2019

机译：合成，表征一些含有1,3,4-二唑和1,3,4-噻二唑部分的一些新的L，3-氧嗪-4-一种衍生物，其具有筛选其一些生物活性。
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6. Synthesis and Evaluation of a Series of 2-Substituted-5-Thiopropylpiperazine (Piperidine)-1,3,4-Oxadiazoles Derivatives as Atypical Antipsychotics [O] . Yin Chen, Xiangqing Xu, Xin Liu, 2009

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机译：衍生1,3,4-二唑的金属配合物的合成与光谱研究，并评价生物活性

Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives.

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