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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Potent neuroprotective role of novel melatonin derivatives for management of central neuropathy induced by acrylamide in rats.
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Potent neuroprotective role of novel melatonin derivatives for management of central neuropathy induced by acrylamide in rats.

机译：新型褪黑激素衍生物对大鼠丙烯酰胺诱导的中枢神经病管理的有效神经保护作用。

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摘要

Acrylamide (ACR) has been shown to be a neurotoxic agent for both laboratory animals and human. The present study aimed at synthesizing new functionalized melatonin derivatives bearing promising heterocyclic moiety that could be expected to have protective effect against ACR-induced neurotoxicity in adult female rats. The novel melatonin derivatives 4, 6, 7 and 11 were synthesized and their chemical structures were confirmed by studying their analytical and spectral data. The administration of ACR [i.p., 50 mg kg(-1) body weight (b. wt.)] alone resulted in significant increase in brain malondialdehyde level (MDA) and lactate dehydrogenase (LDH) activity whereas it caused significant decrease in brain monoamines levels and antioxidant enzymes activity. Treatment with melatonin derivatives 4, 6, 7 and 11 (i.p., 50 mg kg(-1) b. wt) prior to ACR produced significant decrease in brain MDA level and LDH activity with concomitant significant increase in brain monoamines and antioxidant enzymes activity. It could be concluded that the new synthesized melatonin derivatives exhibited promising protective activity against ACR-induced neurotoxicity.
机译：丙烯酰胺（ACR）已被证明是实验室动物和人类的神经毒性剂。本研究旨在合成含有有前途杂环部分的新官能化褪黑激素衍生物，该部分可以预期对成年女性大鼠的ACR诱导的神经毒性具有保护作用。合成了新型褪黑激素衍生物4,6,7和11，通过研究其分析和光谱数据来证实它们的化学结构。单独给予ACR [IP，50mg kg（-1）体重（b。）]脑丙二醛水平（MDA）和乳酸脱氢酶（LDH）活性的显着增加，而它导致脑单胺显着降低水平和抗氧化酶活性。在ACR之前用褪黑激素衍生物4,6,7和11的处理（I.P，50mg kg（-1）b。WT）在脑MDA水平和LDH活性下显着降低，随着脑单胺和抗氧化酶活性的伴随显着增加。可以得出结论，新的合成褪黑素衍生物对来自ACR诱导的神经毒性表现出有前途的保护性。

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