Synthesis, characterization and antimicrobial activity of some disubstituted 1,3,4-oxadiazoles carrying 2-(aryloxymethyl)phenyl moiety.

Naveena CS; Boja P; Kumari NS

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Synthesis, characterization and antimicrobial activity of some disubstituted 1,3,4-oxadiazoles carrying 2-(aryloxymethyl)phenyl moiety.

机译：一些二取代的1,3,4-二氮唑的合成，表征和抗微生物活性携带2-（芳氧基甲基）苯基部分的含量。

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Disubstituted 1,3,4-oxadaiazoles (4a-z, 4a'-f'), Mannich bases (6a-p) and S-alkylated derivatives (7a-t) have been synthesized from 2-(aryloxymethyl)benzoic acids (1a-d) through a multi-step reaction sequence. The structures of new compounds were established on the basis of their elemental analyses, IR, (1)H NMR, (13)C NMR and mass spectral data. All the synthesized compounds were screened for their in vitro antibacterial and antifungal activity and some of them exhibited good activity.

机译：二取代的1,3,4-氧化氮（4a-z，4a'-f'），曼尼奇碱（6a-p）和s-烷基化衍生物（7a-t）已从2-（芳氧羟甲基）苯甲酸（1a -d）通过多步反应序列。基于它们的元素分析，IR，（1）H NMR，（13）C NMR和质谱数据建立新化合物的结构。筛选所有合成的化合物，用于其体外抗菌和抗真菌活性，并且其中一些表现出良好的活性。

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《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2010年第11期|共12页
作者
Naveena CS; Boja P; Kumari NS;
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Department of Chemistry Mangalore University Mangalagangothri-575199 Karnataka India.;

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正文语种 eng
中图分类药学;
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1. Synthesis, characterization and antimicrobial activity of some disubstituted 1,3,4-oxadiazoles carrying 2-(aryloxymethyl)phenyl moiety. [J] . Naveena CS, Boja P, Kumari NS European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：一些带有2-（芳氧基甲基）苯基部分的二取代的1,3,4-恶二唑的合成，表征和抗菌活性。
2. Synthesis, characterization and antimicrobial activity of some disubstituted 1,3,4-oxadiazoles carrying 2-(aryloxymethyl)phenyl moiety. [J] . Naveena CS, Boja P, Kumari NS European Journal of Medicinal Chemistry: Chimie Therapeutique . 2010,第11期

机译：一些二取代的1,3,4-二氮唑的合成，表征和抗微生物活性携带2-（芳氧基甲基）苯基部分的含量。
3. Synthesis, characterization and antimicrobial activity of some 2,5-disubstituted- 3-acetyl-[1,3,4]-oxadiazoles carrying 2-(aryloxymethyl) phenyl moiety [J] . Naveena C.S, Boja Poojary, Manjunath Kumsi, Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry . 2011,第6期

机译：一些带有2-（芳氧基甲基）苯基部分的2,5-二取代-3-乙酰基-[1,3,4]-恶二唑的合成，表征和抗菌活性
4. Study on the Interaction of fluorescent probe 2-(2'-Chloro phenyl)-5-(2'- hydroxyl phenyl)1,3,4-oxadiazole with DNA [C] . Ding Mei, Lei Yingjie, Xu Fang, International Conference on Advanced Engineering Materials and Technology . 2011

机译：荧光探针2-（2'-氯苯基）-5-（2'-羟基苯基）1,3,4-二氧化氮与DNA的相互作用研究
5. Part I: Extension of 1,3,4-oxadiazole chemistry: Studies toward the total synthesis of aspidospermidine. Part II: Progress toward the total synthesis of rebeccamycin [D] . Tao, Houchao 2007

机译：第一部分：1,3,4-恶二唑化学反应的扩展：研究了aspsperspermidine的总合成。第二部分：瑞贝卡霉素全合成的进展
6. Design Synthesis and Anticonvulsant Activity of 2-(2-Phenoxy) phenyl- 134-oxadiazole Derivatives [O] . Sayyed Abbas Tabatabai, Saoka Barghi Lashkari, Mohammad Reza Zarrindast, 2013

机译：2-（2-苯氧基）苯基-134-恶二唑衍生物的设计合成及抗惊厥活性
7. Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivatives [O] . Dilipkumar Pal, Rohit Tripathi, Desh Deepak Pandey, 2014

机译：一些2,5-二取代磺酰氨基1,3,4-恶二唑和2-氨基二取代1,3,4-噻二唑衍生物的合成，表征，抗菌和药理学评价

Synthesis, characterization and antimicrobial activity of some disubstituted 1,3,4-oxadiazoles carrying 2-(aryloxymethyl)phenyl moiety.

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