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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Repurposing ibuprofen to control Staphylococcus aureus biofilms
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Repurposing ibuprofen to control Staphylococcus aureus biofilms

机译：重新培养布洛芬控制金黄色葡萄球菌生物膜

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摘要

Drug repurposing arises as an interesting alternative to overcome the limited efficacy of current available antibiotics by reducing time, cost and risk associated with drug innovation. In this study, the activity of ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), was evaluated on the control of preestablished adhered cells (2 h) and 24 h old biofilms of Staphylococcus aureus. Bacterial adhesion was performed by S. aureus CECT 976, while biofilm formation was also performed by the antibiotic-resistant strains: SA1199B, RN4220 and XU212. The treatment with ibuprofen promoted metabolic reductions up to 80% and total loss of culturability of adhered cells and 24 h old biofilms. Ibuprofen demonstrated moderate efficacy to remove biofilms of S. aureus CECT 976 (removal 2000 mg L-1, respectively. After S. aureus CECT 976 incubation with ibuprofen, cell permeation to propidium iodide, release of intracellular potassium and changes on cell surface hydrophobicity were observed. The overall results, demonstrate that ibuprofen can control S. aureus planktonic and sessile growth, with strong destabilizing and disrupting action on the cytoplasmic membrane. (C) 2019 Elsevier Masson SAS. All rights reserved.
机译：药物重新淘汰作为一个有趣的替代方案，通过减少与药物创新相关的时间，成本和风险来克服当前可用抗生素的有限疗效。在这项研究中，布洛芬的活性，非甾体抗炎药（NSAID），于预先建立贴壁细胞（2小时）和金黄色葡萄球菌24小时老生物膜的控制进行评价。细菌粘附通过S. aureus Cect 976进行，而Biofilm形成也通过抗生素抗性菌株：SA1199B，RN4220和XU212进行。与布洛芬的处理促进了粘附细胞和24小时粘附细胞培养性的80％和培养性的总损失。布洛芬证明中等效力，以除去生物膜的金黄色葡萄球菌CECT 976（去除2000毫克L-1，分别。金黄色葡萄球菌CECT 976孵育布洛芬，细胞渗透到碘化丙锭，细胞内的钾和细胞表面上的疏水性变化的发布后观察到的。总体结果表明，布洛芬可以控制金黄色菌氏菌和术治疗，具有较强的破坏性和破坏细胞质膜的作用。（c）2019年Elsevier Masson SAS。保留所有权利。

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