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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Biological applications of near infrared fluorescence dye probes in monitoring Alzheimer's disease
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Biological applications of near infrared fluorescence dye probes in monitoring Alzheimer's disease

机译：近红外荧光染料探针在监测Alzheimer疾病中的生物学应用

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摘要

Alzheimer's disease (AD) is characterized by progressive decrease in cognitive abilities, language impairment and irreversible memory loss. Amyloid-beta (A beta) and tau deposits are essential as the major factors involved in the pathogenesis of AD. Unfortunately, anti-Alzheimer's disease agents currently available are not potent enough to reverse the cause of the disease. Interestingly, near infrared fluorescence (NIRF) dyes have been marked as promising tools in analytical researches and are often adopted as molecular probes to monitor and diagnose AD, in vitro or in vivo. Compared with other imaging techniques, such as positron emission tomography (PET), magnetic resonance imaging (MRI), and single-photon emission computed tomography (SPECT), NIRF dye probes have been applied in AD pre-clinical trials and have gained rapid benefits, in view of their advantages including real time imaging, biocompatibility, high selectivity and sensitivity, high spatiotemporal resolution, and easy data analysis. This work reviews the developmental design of typical NIRF dye probes in monitoring A beta s and tau species in the brain of AD model mice and patients. (C) 2019 Elsevier Masson SAS. All rights reserved.
机译：阿尔茨海默病（AD）的特点是认知能力，语言障碍和不可逆转记忆损失的逐步降低。淀粉样蛋白 - β（β）和Tau沉积物至关重要作为参与广告发病机制的主要因素。不幸的是，目前可用的抗阿尔茨海默病剂不足以逆转疾病的原因。有趣的是，近红外荧光（NIRF）染料已被标记为分析研究中的有前途的工具，并且通常是用于监测和诊断AD，体内或体内的分子探针。与其他成像技术相比，例如正电子发射断层扫描（PET），磁共振成像（MRI）和单光子发射计算断层摄影（SPECT），NIRF染料探针已在AD临床前试验中应用，并获得了快速的益处，鉴于它们的优点，包括实时成像，生物相容性，高选择性和敏感性，高时的时尚分辨率以及易于数据分析。这项工作审查了典型的NIRF染料探头的发育设计在广告模型小鼠和患者的脑中监测ββ和TAU物种。 （c）2019年Elsevier Masson SAS。版权所有。

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