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Inhibition of vertebrate aldehyde oxidase as a therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis

机译:脊椎醛氧化酶的抑制作用作为癌症,肥胖,衰老和肌萎缩侧面硬化症的治疗治疗

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摘要

The aldehyde oxidases (AOXs) are a small sub-family of cytosolic molybdo-flavoenzymes, which are structurally conserved proteins and broadly distributed from plants to animals. AOXs play multiple roles in both physiological and pathological processes and AOX inhibition is of increasing significance in the development of novel drugs and therapeutic strategies. This review provides an overview of the evolution and the action mechanism of AOX and the role of each domain. The review provides an update of the polymorphisms in the human AOX. This review also summarises the physiology of AOX in different organs and its role in drug metabolism. The inhibition of AOX is a promising therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis. (C) 2019 Elsevier Masson SAS. All rights reserved.
机译:醛氧化酶(AOXs)是细胞溶质钼 - 黄酶的小亚类,其是在结构上保守的蛋白质,并广泛地分布于动物到动物。 Aoxs在生理和病理过程中发挥多种作用,AOX抑制在新药和治疗策略的发展方面具有显着性。 此审查概述了AOX的演变和AX的动作机制以及每个域的角色。 审查提供了人类AOX中的多态性的更新。 该评价还总结了不同器官AX的生理学及其在药物代谢中的作用。 抑制AOX是癌症,肥胖,衰老和肌萎缩侧硬化的有希望的治疗治疗。 (c)2019年Elsevier Masson SAS。 版权所有。

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