Design, synthesis and cytotoxicity studies of novel pyrazolo[1, 5-a] pyridine derivatives

Ravi Chitrakar; Qayum Arem; Mohan Darapaneni Chandra; Singh Shashank K.; Adimurthy Subbarayappa

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Design, synthesis and cytotoxicity studies of novel pyrazolo[1, 5-a] pyridine derivatives

机译：新型吡唑的设计，合成和细胞毒性研究[1,5-A]吡啶衍生物

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Copper mediated synthesis of various pyrazolo[1, 5 a]pyridine-3-carboxylates has been described. The biological activities of these molecules have been evaluated against various human cancer cell lines A549 (Lung adenocarcinoma cell line), MCF-7 (Breast carcinoma cell line), HCT-116 (Colon cancer cell line), and PC-3 (Prostate cancer cell line) through SRB assay. Compound 247 led to accumulation MCF-7 cells in G1-phase and revealed its important role in mitotic cell cycle progression. (C) 2016 Elsevier Masson SAS. All rights reserved.

机译：已经描述了铜介导的各种吡唑[1,5a]吡啶-3-羧酸酯的合成。已经对各种人类癌细胞系A549（肺腺癌细胞系），MCF-7（乳腺癌细胞系），HCT-116（结肠癌细胞系）和PC-3（前列腺癌（前列腺癌）评估了这些分子的生物活性。细胞系）通过SRB测定。化合物247导致G1相中累积MCF-7细胞，并在有丝分裂细胞周期进展中揭示了其重要作用。（c）2016年Elsevier Masson SAS。版权所有。

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来源
《European Journal of Medicinal Chemistry: Chimie Therapeutique》 |2017年第2017期|共9页
作者
Ravi Chitrakar; Qayum Arem; Mohan Darapaneni Chandra; Singh Shashank K.; Adimurthy Subbarayappa;
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作者单位

Cent Salt &

Marine Chem Res Inst CSIR Acad Sci &

Innovat Res Nat Prod &

Green Chem Div GB Marg;

CSIR Indian Inst Integrat Med Jammu 180001 India;

Cent Salt &

Marine Chem Res Inst CSIR Acad Sci &

Innovat Res Nat Prod &

Green Chem Div GB Marg;

CSIR Indian Inst Integrat Med Jammu 180001 India;

Cent Salt &

Marine Chem Res Inst CSIR Acad Sci &

Innovat Res Nat Prod &

Green Chem Div GB Marg;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Pyrazolo1; 5-apyridines; Cytotoxicity; MCF-7 cells; Growth inhibition; SRB assay;

机译：吡唑洛[1;5-A]吡啶;细胞毒性;MCF-7细胞;生长抑制;SRB测定;

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1. Design, synthesis and cytotoxicity studies of novel pyrazolo[1, 5-a] pyridine derivatives [J] . Ravi Chitrakar, Qayum Arem, Mohan Darapaneni Chandra, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2017,第期

机译：新型吡唑的设计，合成和细胞毒性研究[1,5-A]吡啶衍生物
2. Studies with polyfunctionally substituted heterocycles: New synthesis of pyrido[5 ',4 ': 2,3][1,3,4]oxadiazolo[3,2-a]pyridine; pyridazine; 1,3,4-oxadiazole; and Pyrazolo[1,5-a]pyrimidine derivatives [J] . Barsy MA., Ahmed SM., Elmaghraby MA. Journal of the Chinese Chemical Society. . 1998,第5期

机译：多官能取代杂环的研究：吡啶并[5'，4'：2,3] [1,3,4]恶二唑并[3,2-a]吡啶的新合成;哒嗪1,3,4-恶二唑;和吡唑并[1,5-a]嘧啶衍生物
3. Structure-based design, synthesis, and study of pyrazolo(1,5-a)(1,3,5)triazine derivatives as potent inhibitors of protein kinase CK2. [J] . Nie Z, Perretta C, Erickson P, Bioorganic and Medicinal Chemistry Letters . 2007,第15期

机译：吡唑并（1,5-a）（1,3,5）三嗪衍生物作为蛋白激酶CK2的有效抑制剂的基于结构的设计，合成和研究。
4. New Electron Donors: TTF Derivatives Bearing Pyridine Groups: Synthesis andElectrochemical Studies [C] . Chuyang Jia China-Japan joint symposium on conduction and photoconduction in organic solids and related phenomena;CJOSS-7 . 2001

机译：新的电子给体：带有吡啶基的TTF衍生物：合成和电化学研究
5. Spectroscopic studies on carborane derivatives: Synthesis and characterization of partial cage degradation reactions of 1,2-(hydroxymethyl radical)-closo-carborane with 2-(aminomethyl)-pyridine. [D] . Gilbes, Blanca Janet. 2006

机译：碳硼烷衍生物的光谱研究：1,2-（羟甲基自由基）-氯甲烷与2-（氨基甲基）-吡啶的部分笼降解反应的合成和表征。
6. Synthesis of some new pyrazolo15-apyrimidine pyrazolo51-ctriazine 134-thiadiazole and pyridine derivatives containing 123-triazole moiety [O] . Nadia A. Abdelriheem, Yasser H. Zaki, Abdou O. Abdelhamid 2017

机译：合成一些新的吡唑并15-a嘧啶吡唑并51-c三嗪134-噻二唑和含有123-三唑部分的吡啶衍生物
7. Synthesis of new pyrazolo[3,4-b]pyridines and pyrazolo[1,5-a]pyrimidine and study of the pyrazolic nitrogen reactivity [O] . Mostafa Khouili, Salah Fadel, Salha Hamri, 2010

机译：新型吡唑并[3,4-b]吡啶和吡唑并[1,5-a]嘧啶的合成及吡唑氮反应性研究

Design, synthesis and cytotoxicity studies of novel pyrazolo[1, 5-a] pyridine derivatives

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