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首页> 外文期刊>Medical Physics >SU‐F‐T‐192: Study of Robustness Analysis Method of Multiple Field Optimized IMPT Plans for Head & Neck Patients
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SU‐F‐T‐192: Study of Robustness Analysis Method of Multiple Field Optimized IMPT Plans for Head & Neck Patients

机译：SU-F-T-192：多场多场优化IMPT计划的鲁棒性分析方法研究头颈患者

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Purpose: Proton therapy is more sensitive to uncertainties than photon treatments due to protons’ finite range depending on the tissue density. Worst case scenario (WCS) method originally proposed by Lomax has been adopted in our institute for robustness analysis of IMPT plans. This work demonstrates that WCS method is sufficient enough to take into account of the uncertainties which could be encountered during daily clinical treatment. Methods: A fast and approximate dose calculation method is developed to calculate the dose for the IMPT plan under different setup and range uncertainties. Effects of two factors, inversed square factor and range uncertainty, are explored. WCS robustness analysis method was evaluated using this fast dose calculation method. The worst‐case dose distribution was generated by shifting isocenter by 3 mm along x,y and z directions and modifying stopping power ratios by ±3.5%. 1000 randomly perturbed cases in proton range and x, yz directions were created and the corresponding dose distributions were calculated using this approximated method. DVH and dosimetric indexes of all 1000 perturbed cases were calculated and compared with the result using worst case scenario method. Results: The distributions of dosimetric indexes of 1000 perturbed cases were generated and compared with the results using worst case scenario. For D95 of CTVs, at least 97% of 1000 perturbed cases show higher values than the one of worst case scenario. For D5 of CTVs, at least 98% of perturbed cases have lower values than worst case scenario. Conclusion: By extensively calculating the dose distributions under random uncertainties, WCS method was verified to be reliable in evaluating the robustness level of MFO IMPT plans of H&N patients. The extensively sampling approach using fast approximated method could be used in evaluating the effects of different factors on the robustness level of IMPT plans in the future.
机译：目的：质子疗法对不确定性比Photon治疗更敏感，这取决于组织密度。 Lomax最初提出的最糟糕的情况（WCS）方法已在IMPT计划的鲁棒性分析研究所中采用。这项工作表明，WCS方法足以考虑到日常临床治疗期间可能遇到的不确定性。方法：开发了一种快速且近似的剂量计算方法，以计算不同的设置和范围不确定性下的IMPT计划的剂量。探讨了两个因素，反向平方根和范围不确定性的影响。使用这种快速剂量计算方法评估WCS鲁棒性分析方法。通过沿x，y和z方向向3mm转移3mm并通过±3.5％改变停止功率比来产生最坏情况的剂量分布。在质子范围和x中的1000随机扰动病例被产生，使用该近似方法计算相应的剂量分布。计算所有1000个扰动案例的DVH和剂量索引，并使用最坏情况下的结果进行比较。结果：生成了1000例扰动病例的剂量分布，并与使用最坏情况场景的结果进行了比较。对于CTV的D95，至少97％的1000个扰动病例中的值高于最坏情况场景之一。对于CTV的D5，至少98％的扰动病例的值比最坏情况更低。结论：通过广泛地计算随机不确定性下的剂量分布，验证了WCS方法可靠地评估H＆amp的MFO IMPT计划的鲁棒性水平。使用快速近似方法的广泛采样方法可用于评估不同因素对未来IMPT计划的稳健性水平的影响。

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