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首页> 外文期刊>Molecular medicine reports >Analysis of intestinal microbial communities of cerebral infarction and ischemia patients based on high throughput sequencing technology and glucose and lipid metabolism
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Analysis of intestinal microbial communities of cerebral infarction and ischemia patients based on high throughput sequencing technology and glucose and lipid metabolism

机译：基于高通量测序技术和葡萄糖和脂质代谢的脑梗死和缺血患者肠道微生物患者分析

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摘要

Currently, cerebral infarction (CI) is the leading cause of disability and the second leading cause of mortality in China, seriously affecting patient quality of life. Ischemia (IS) is considered to be the early stage of CI. The present study aims to investigate the variation of intestinal microbial communities in patients with CI and IS using high throughput sequencing technology, and then analyze the results to identify a novel potential pathogenic mechanism of CI and IS. In total, 8 patients with CI, 2 patients with IS and 10 healthy volunteers as a control were selected. Throughput sequencing technology was used to analyze the character and microbial population of the gut. The abundance of Escherichia, Bacteroides, Megamonas, Parabacteroides, Akkermansia, Prevotella, Faecalibacterium, Dialister, Bifidobacterium and Ruminococcus was the significant difference in the intestinal microbial communities of the CI and IS patients compared with the healthy group. It was also observed that CI and IS were closely associated with internal glucose metabolism. The intestinal gut disturbance of CI patients may be one of the causes inducing CI by glucose metabolism and maybe considered as a potential method to predict the disease.
机译：目前，脑梗死（CI）是中国残疾的主要原因和中国死亡率的第二个主要原因，严重影响患者的生活质量。缺血（是）被认为是CI的早期阶段。本研究旨在探讨CI患者肠道微生物群落的变异，并使用高通量测序技术，然后分析结果以确定CI的新潜在致病机制。选择总共8例CI，2例患者和10名健康志愿者作为对照。吞吐量测序技术用于分析肠道的角色和微生物群。大量的大肠杆菌，诱导菌，巨奶体，粉末阳，αkkermansia，pharotella，粪便杆菌，拨号，双歧杆菌和谣言，与健康组的肠道微生物群落是肠道微生物群落的显着差异。还观察到CI和与内部葡萄糖代谢密切相关。 CI患者的肠道肠道扰动可能是葡萄糖代谢诱导CI的原因之一，也许被认为是预测疾病的潜在方法。

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  • 来源
    《Molecular medicine reports》 |2017年第3期|共5页
  • 作者

    Ji Wenzhen; Zhu Yu; Kan Pengcheng; Cai Ying; Wang Zhida; Wu Zijian; Yang Ping;

  • 作者单位

    Tianjin Huanhu Hosp Tianjin Key Lab Cerebral Vessels &

    Neural Degener Dept Neurol Tianjin 300350;

    Tianjin Huanhu Hosp Tianjin Key Lab Cerebral Vessels &

    Neural Degener Dept Clin Lab 6 Jizhao Rd;

    Tianjin Huanhu Hosp Tianjin Key Lab Cerebral Vessels &

    Neural Degener Dept Clin Lab 6 Jizhao Rd;

    Tianjin Huanhu Hosp Tianjin Key Lab Cerebral Vessels &

    Neural Degener Tianjin Neurosurg Inst;

    Tianjin Med Univ Metab Dis Hosp Dept Renal Dis Tianjin 300070 Peoples R China;

    Tianjin Univ Commerce Coll Biotechnol &

    Food Sci Tianjin Key Lab Food Biotechnol Tianjin 300134;

    Tianjin Huanhu Hosp Tianjin Key Lab Cerebral Vessels &

    Neural Degener Dept Clin Lab 6 Jizhao Rd;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 基础医学;
  • 关键词

    cerebral infarction; intestinal microbial communities; sequencing technology;

    机译：脑梗塞;肠道微生物社区;测序技术;

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