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Cerasome-based gold-nanoshell encapsulating L-menthol for ultrasound contrast imaging and photothermal therapy of cancer

机译：基于Cirasome的Gold-Nanoshell封装L-Menthol以进行超声对比度成像和癌症的光热疗法

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摘要

Various nanoformulations of perfluorocarbon have been developed thus far, to achieve ultrasound imaging of tumors and tumor-targeted therapy. However, their application has been greatly limited by their short sonographic duration and large size distribution. A novel theranostic agent was constructed based on gold nanoshell cerasome-encapsulated L-menthol (GNC-LM). Owing to the sustained and controllable generation of L-menthol bubbles under near-infrared laser irradiation, GNC-LM showed good performance in contrast enhancement of ultrasound imaging in vivo. GNC-LM could be imaged for 30 min, which is much longer than the imaging time of SonoVue (commercially used microbubbles). Moreover, photothermal therapy (PTT) based on the light-to-heat conversion of the nanosystem effectively ablated the tumor. Our study demonstrated the promising potential of the obtained GNC-LM to serve as a therapeutic nanoprobe for ultrasound contrast imaging and PTT of tumors.
机译：到目前为止，已经开发了各种全氟化碳的纳米氧化物，以实现肿瘤和肿瘤靶向治疗的超声成像。 但是，它们的应用受到它们的短暂超声持续时间和大尺寸分布的极大限制。 基于金纳米硒包裹的L-薄荷醇（GNC-LM）构建了一种新型的治疗剂。 由于近红外激光照射下的L-MENTHOL气泡的持续和可控的产生，GNC-LM在体内超声成像的对比度方案表现出良好的性能。 GNC-LM可以成像30分钟，比Sonovue的成像时间长得多（商业用过的微泡）。 此外，基于纳米系统的光热转化的光热疗法（PTT）有效地烧蚀了肿瘤。 我们的研究证明了所得GNC-LM的有希望的电位，用作用于超声对比度成像和肿瘤PTT的治疗纳米孔。

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  • 来源
    《Nanotechnology》 |2019年第1期|共9页
  • 作者

    Guan Qingqing; Wang Chunan; Wu Dan; Wang Wei; Zhang Chunyang; Liu Jie; Xu Ming; Shuai Xintao; Wang Zhu; Cao Zhong;

  • 作者单位

    Sun Yat Sen Univ Sch Biomed Engn Guangdong Prov Key Lab Sensor Technol &

    Biomed In Guangzhou Higher Educ Mega Ctr 132 East Waihuan Rd Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Biomed Engn Guangdong Prov Key Lab Sensor Technol &

    Biomed In Guangzhou Higher Educ Mega Ctr 132 East Waihuan Rd Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Biomed Engn Guangdong Prov Key Lab Sensor Technol &

    Biomed In Guangzhou Higher Educ Mega Ctr 132 East Waihuan Rd Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Affiliated Hosp 1 Dept Med Ultrasound Inst Diagnost &

    Intervent Ultrasound 58 Zhongshan Rd 2 Guangzhou 510080 Guangdong Peoples R China;

    Sun Yat Sen Univ Affiliated Hosp 1 Dept Med Ultrasound Inst Diagnost &

    Intervent Ultrasound 58 Zhongshan Rd 2 Guangzhou 510080 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Biomed Engn Guangdong Prov Key Lab Sensor Technol &

    Biomed In Guangzhou Higher Educ Mega Ctr 132 East Waihuan Rd Guangzhou 510006 Guangdong Peoples R China;

    Sun Yat Sen Univ Affiliated Hosp 1 Dept Med Ultrasound Inst Diagnost &

    Intervent Ultrasound 58 Zhongshan Rd 2 Guangzhou 510080 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Chem &

    Chem Engn Minist Educ PCFM Lab 135 West Xingang Rd Guangzhou 510275 Guangdong Peoples R China;

    Sun Yat Sen Univ Affiliated Hosp 1 Dept Med Ultrasound Inst Diagnost &

    Intervent Ultrasound 58 Zhongshan Rd 2 Guangzhou 510080 Guangdong Peoples R China;

    Sun Yat Sen Univ Sch Biomed Engn Guangdong Prov Key Lab Sensor Technol &

    Biomed In Guangzhou Higher Educ Mega Ctr 132 East Waihuan Rd Guangzhou 510006 Guangdong Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 特种结构材料;
  • 关键词

    theranostic; ultrasound contrast agents; hybrid liposome; microbubbles; near-infrared laser;

    机译：Theranostic;超声造影剂;杂交脂质体;微泡;近红外激光;

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