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Immobilization of novel inorganic nano-complexes onto MWCNT nanomaterials as a novel adsorbent and anti-inflammatory therapy in an induced model of rheumatoid arthritis

机译:将新型无机纳米复合物固定到MWCNT纳米材料中作为类风湿性关节炎诱导模型的新型吸附剂和抗炎疗法

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Novel supported inorganic metal nano-complexes of Ag(I) and Co(II) derived from 4-amino-N-(4-methylpyrimidin-2-yl) benzene sulfonamide (SulMer) were synthesized using olive leaf extract as a reducing agent with grinding and microwave methods. The prepared samples were denoted as Comp1-6. The surface morphologies of the synthesized nanomaterials were analyzed using C, H, N, S analysis, Fourier-transform infrared spectroscopy, UV- visible spectroscopy, proton and carbon nuclear magnetic resonance, scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and x-ray powder diffraction (XRD) analysis. The data revealed that all the synthesized complexes exhibited a 1:1 metal-to-ligand ratio with a coordination number of 4 or 6. The mean particle size of the nanomaterial samples was 25-35 nm. The XRD patterns indicated a crystalline nature for the complexes. The supported inorganic metal nano-complexes displayed good activity in the adsorptive removal of Direct Red 81 (DR-81) from aqueous solutions. In addition, the effect of the supported metal nano-complexes on the immune system was studied as well as how these anti-inflammatory compounds could be used to treat many autoimmune diseases, most notably rheumatoid arthritis. An experimental model for arthritis can be induced using complete Freund's adjuvant. It was shown that the supported complex offers several advantages such stability, eco-friendliness, simple experimental conditions, short reaction times, and easy work- up.
机译:使用橄榄叶提取物作为还原剂合成来自4-氨基-N-(4-甲基吡啶-2-基)苯磺酰胺(硫醇)的Ag(I)和CO(II)的新型Ag(I)和CO(II)的新型Ag(I)和CO(II)的纳米络合物研磨和微波方法。制备的样品被表示为COMP1-6。使用C,H,N,S分析,傅立叶变换红外光谱,UV-可见光谱,质子和碳核磁共振,扫描电子显微镜,透射电子显微镜,热重分析和X分析合成纳米材料的表面形态学。 -Reay粉末衍射(XRD)分析。数据表明,所有合成的复合物表现出1:1的金属到配体的比率与配位数4或6所述纳米材料样品的平均粒径为25-35纳米。 XRD图案表明了复合物的结晶性质。支持的无机金属纳米复合物在从水溶液中呈现出良好的红外线81(DR-81)的良好活性。此外,研究了负载的金属纳米复合物对免疫系统的影响以及这些抗炎化合物如何用于治疗许多自身免疫性疾病,最符说的类风湿性关节炎。使用完全弗氏佐剂可以诱导关节炎的实验模型。结果表明,支持的复合物提供了多种优势,这种稳定性,生态友好性,简单的实验条件,反应时间短,易于工作。

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