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首页> 外文期刊>Nanotechnology >Single-step synthesis of Er3+ and Yb3+ ions doped molybdate/Gd2O3 core-shell nanoparticles for biomedical imaging
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Single-step synthesis of Er3+ and Yb3+ ions doped molybdate/Gd2O3 core-shell nanoparticles for biomedical imaging

机译：ER3 +和YB3 +离子的单步合成掺杂钼酸盐/ Gd2O3核 - 壳纳米粒子用于生物医学成像

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Nanostructures as color-tunable luminescent markers have become major, promising tools for bioimaging and biosensing. In this paper separated molybdate/Gd2O3 doped rare earth ions (erbium, Er3+ and ytterbium, Yb3+) core-shell nanoparticles (NPs), were fabricated by a one-step homogeneous precipitation process. Emission properties were studied by cathodo- and photoluminescence. Scanning electron and transmission electron microscopes were used to visualize and determine the size and shape of the NPs. Spherical NPs were obtained. Their core-shell structures were confirmed by x-ray diffraction and energy-dispersive x-ray spectroscopy measurements. We postulated that the molybdate rich core is formed due to high segregation coefficient of the Mo ion during the precipitation. The calcination process resulted in crystallization of delta/xi (core/shell) NP doped Er and Yb ions, where delta-gadolinium molybdates and xi-molybdates or gadolinium oxide. We confirmed two different upconversion mechanisms. In the presence of molybdenum ions, in the core of the NPs, Yb3+-MoO4-2 (vertical bar F-2(7/2), T-3(2)>) dimers were formed. As a result of a two 980 nm photon absorption by the dimer, we observed enhanced green luminescence in the upconversion process. However, for the shell formed by the Gd2O3:Er, Yb NPs (without the Mo ions), the typical energy transfer upconversion takes place, which results in red luminescence. We demonstrated that the NPs were transported into cytosol of the HeLa and astrocytes cells by endocytosis. The core-shell NPs are sensitive sensors for the environment prevailing inside (shorter luminescence decay) and outside (longer luminescence decay) of the tested cells. The toxicity of the NPs was examined using MTT assay.
机译：纳米结构作为颜色可调发光标记已成为生物染色和生物传感的主要型工具。在本文中，通过一步均匀的沉淀方法，通过单步均匀沉淀法制造了分离的钼酸盐/ Gd2O3掺杂稀土离子（铒，ER3 +和镱，YB3 +）核 - 壳纳米粒子（NPS）。通过Cathodo-和光致发光研究了发射性能。扫描电子和透射电子显微镜用于可视化并确定NPS的尺寸和形状。获得球形NPS。通过X射线衍射和能量分散X射线光谱测量来证实它们的核心壳结构。我们假设由于沉淀过程中Mo离子的高偏析系数，因此形成富含富含摩利酸的芯。煅烧过程导致Delta / Xi（核/壳）NP掺杂ER和YB离子的结晶，其中Delta-钆钼酸盐和氧化氢盐或氧化钆。我们确认了两种不同的上转换机制。在钼离子存在下，在NPS的核心中，形成YB3 + -MOO4-2（垂直棒F-2（7/2），T-3（2）>）二聚体。由二聚体的两个980nm的光子吸收的结果，我们观察到增强的绿色发光在上变化过程中。然而，对于由Gd2O3：ER，Yb NPS（没有Mo离子）形成的壳，发生了典型的能量转移，其导致红色发光。我们证明NPS通过内吞作用将NPS转运成HeLa和星形胶质细胞细胞的细胞溶胶。核心壳NPS是用于在测试单元的内部（短发发光衰减）和外部（更长发光衰减）的环境敏感传感器。使用MTT测定检查NPS的毒性。

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