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Cytotoxicity control of silicon nanoparticles by biopolymer coating and ultrasound irradiation for cancer theranostic applications

机译：生物聚合物涂层硅纳米颗粒的细胞毒性控制和癌症治疗癌症的超声辐照

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摘要

Silicon nanoparticles (SiNPs) prepared by mechanical grinding of luminescent porous silicon were coated with a biopolymer (dextran) and investigated as a potential theranostic agent for bioimaging and sonodynamic therapy. Transmission electron microscopy, photoluminescence and Raman scattering measurements of dextran-coated SiNPs gave evidence of their enhanced stability in water. In vitro experiments confirmed the. lower cytotoxicity of the dextran-coated NPs. in comparison with uncoated ones, especially for. high concentrations of about 2 mg ml(-1). Efficient uptake of the NPs. by cancer cells was found using bioimaging in the optical transmittance and photoluminescence modes. Treatment. of the cells with uptaken SiNPs by therapeutic ultrasound for 5-20 min resulted in a strong decrease in. the number of. living cells, while the total number of cells remained nearly unchanged. The obtained data indicate a ` mild' effect of the combined action of ultrasonic irradiation. and SiNPs on cancer cells. The observed results reveal new opportunities for. controlling the photoluminescent and sonosensitizing properties of silicon-based NPs. for applications in the diagnostics and mild therapy of cancer.
机译：通过机械研磨的发光多孔硅制备的硅纳米颗粒（SINPS）用生物聚合物（葡聚糖）涂覆，并作为生物分析和超声动力治疗的潜在治疗剂。透射电子显微镜，光致发光和葡聚糖涂层SINPS的散射测量，证明了它们在水中增强的稳定性。体外实验证实了。降低葡聚糖涂层NPS的细胞毒性。与未经涂覆的相比，特别是。高浓度约2mgml（-1）。高效摄取NPS。发现使用癌细胞在光学透射率和光致发光模式中使用生物分析。治疗。通过治疗超声升高的辛汗的细胞5-20分钟导致强劲下降。的数量。活细胞，而细胞总数仍然几乎没有变化。所获得的数据表明超声辐射的组合作用的“轻度”效应。和癌细胞上的sinps。观察结果揭示了新的机会。控制基于硅基NPS的光致发光和超声敏感性。用于诊断和癌症的温和治疗的应用。

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