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首页> 外文期刊>Nanotechnology >Cyclodextrin-gated mesoporous silica nanoparticles as drug carriers for red light-induced drug release
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Cyclodextrin-gated mesoporous silica nanoparticles as drug carriers for red light-induced drug release

机译：环糊精的中孔二氧化硅纳米粒子作为红色光诱导药物释放的药物载体

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摘要

Long wavelength light-responsive drug delivery systems based on mesoporous silica nanoparticles (MSNs) have attracted much attention in the last few years. In this paper, a red light (660 nm)-responsive drug delivery system based on low-cost cyclodextrin (CD)-gated MSNs containing a photodynamic therapy (PDT) photosensitizer (Chlorin e6, Ce6) was developed for the first time. The drug release experiment in water demonstrated that with the irradiation of red light, Ce6 can be excited to generate singlet oxygen, which can further cleave the singlet oxygen sensitive linker to trigger the departure of CD and the release of cargo. Further in vitro release experiments confirmed that cargo can be released from MSNs with the irradiation of red light and spread into the entire cell. The relative low power density (0.5Wcm(-2)) of excitation light together with the short irradiation time (one-three min) result in a low light dose (30-90 J cm(-2)) for the drug delivery, contributing to their potential clinical applications.
机译：基于中孔二氧化硅纳米粒子（MSNS）的长波长光响应药物递送系统在过去几年中引起了很多关注。本文首次开发了基于低成本环糊精（CD） - 含有光动力疗法（PDT）光敏剂（PDT）光敏剂（CALLIN E6，CE6）的低成本环糊精（CD）型MSN的红光（660nm） - 夸张的药物递送系统。水中的药物释放实验证明，随着红光的照射，CE6可以兴奋地产生单线氧，这可以进一步切割单次氧敏感接头以触发CD的偏离和释放货物。进一步的体外释放实验证实，货物可以通过MSN释放红光灯并涂抹到整个细胞中。激发光的相对低功率密度（0.5wcm（-2））与短照射时间（一三分钟）导致低光剂量（30-90J厘米（-2）），用于药物递送，为他们的潜在临床应用贡献。

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  • 来源
    《Nanotechnology》 |2017年第14期|共10页
  • 作者

    Chai Shiqiang; Guo Yu; Zhang Zhenyu; Chai Zhen; Ma Yurong; Qi Limin;

  • 作者单位

    Peking Univ Beijing Natl Lab Mol Sci Coll Chem &

    Mol Engn State Key Lab Struct Chem Unstable &

    Stable Speci Beijing 100871 Peoples R China;

    Peking Univ Coll Life Sci State Key Lab Membrane Biol Beijing 100871 Peoples R China;

    Peking Univ Key Lab Polymer Chem &

    Phys Ctr Soft Matter Sci &

    Engn Minist Educ Coll Chem &

    Mol Engn Beijing Natl Lab Beijing 100871 Peoples R China;

    Peking Univ Coll Life Sci State Key Lab Membrane Biol Beijing 100871 Peoples R China;

    Peking Univ Beijing Natl Lab Mol Sci Coll Chem &

    Mol Engn State Key Lab Struct Chem Unstable &

    Stable Speci Beijing 100871 Peoples R China;

    Peking Univ Beijing Natl Lab Mol Sci Coll Chem &

    Mol Engn State Key Lab Struct Chem Unstable &

    Stable Speci Beijing 100871 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 特种结构材料;
  • 关键词

    mesoporous silica nanoparticles; photodynamic therapy; drug delivery; cyclodextrin;

    机译：中孔二氧化硅纳米粒子;光动力疗法;药物递送;环糊精;

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