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首页> 外文期刊>Nanotechnology >Investigation of novel superparamagnetic Ni0.5Zn0.5Fe2O4@albumen nanoparticles for controlled delivery of anticancer drug
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Investigation of novel superparamagnetic Ni0.5Zn0.5Fe2O4@albumen nanoparticles for controlled delivery of anticancer drug

机译：新型超顺磁Ni0.5Zn0.5Fe2O4的调查抗癌药物控制递送的纳米粒子

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In the present work, multifunctional Ni0.5Zn0.5Fe2O4@albumen (NZF@Alb) and doxorubicin-loaded Ni0.5Zn0.5Fe2O4@albumen (NZF@Alb-Dox) core-shell nanoparticles have been prepared by a green and simple method using inexpensive chicken egg albumen and have been characterized for different physiochemical properties. The structural, morphological, thermal, and magnetic properties of the prepared nanoparticles have been investigated by an x-ray diffractometer, high-resolution transmission electron microscopy (HRTEM), field emission scanning electron microscopy, sFourier-transformed infrared, thermogravimetric analysis, and vibrating sample magnetometer techniques. Superparamagnetic Ni0.5Zn0.5Fe2O4 nanoparticles (NZF NPs) with the mean size similar to 20 nm were coated with albumen matrix by an ultrasonication process. Inverse fast Fourier transform-assisted HRTEM micrographs and FTIR analysis revealed the coating of amorphous albumen on crystalline NZF NPs. NZF@Alb and NZF@Alb-Dox NPs have the mean size (D50) of similar to 100 nm, good stability, and magnetic controllability. Magnetic measurements (field (H)-dependent magnetization (M)) show all samples to be super-paramagnetic in nature. Biocompatibilities of the NZF and NZF@Alb NPs were confirmed by in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against RAW 264.7 cells. NZF@Alb NPs have been found to be more biocompatible than bare NZF. In Vitro Dox release behavior from NZF@Alb-Dox NPs has been studied at pH 7.4 and 5, and a sustained and pH-dependent drug release profile were observed. In vitro cytotoxicity or anticancer activity of the blank NZF@Alb NPs, free Dox, and NZF@Alb-Dox NPs against HeLa cells (cancer cell line) were also examined by MTT assay. The obtained results suggest that this scalable egg-albumen-based magnetic nanoformulation is suitable for targeted drug delivery applications. Thus, the present study could be extremely useful for the advancement of albumin-based nanocarrier design and development for biomedical applications such as targeted and controlled delivery of anticancer drugs.
机译：另外，在本工作中，多官能Ni0.5Zn0.5Fe2O4@albumen（NZF @ ALB）和负载阿霉素的Ni0.5Zn0.5Fe2O4@albumen（NZF @ ALB-Dox的）芯 - 壳纳米颗粒已经制备通过使用绿色和简单的方法便宜的鸡蛋蛋白和的特点为不同的理化性质。所制备的纳米颗粒的结构，形态，热和磁特性已通过x射线衍射仪，高分辨率透射电子显微镜（HRTEM），场发射扫描电子显微镜研究，sFourier变换红外，热重分析，和振动样品磁技术。超顺磁性纳米颗粒结晶体Ni0.5Zn0.5Fe2O4（NZF NPS）具有类似于20nm的平均尺寸涂有通过超声波处理蛋白基质。快速傅立叶逆变换辅助HRTEM显微照片和FTIR分析显示无定形蛋白的涂层上结晶NZF的NP。 NZF @白蛋白和NZF @ ALB-Dox的纳米颗粒具有类似〜100nm的平均粒径（D50），良好的稳定性和磁性控制性。磁测量（场（H） - 依赖性的磁化（M））显示所有样品在本质上的超顺磁性。的NZF和NZF @白蛋白NP的生物相容性通过体外3-（4,5-二甲基噻唑-2-基）对RAW 264.7细胞-2,5-二苯基溴化物（MTT）测定法证实。 NZF @白蛋白纳米粒子被发现是比裸NZF更多的生物相容性。在从NZF @ ALB-Dox的纳米粒体外DOX释放行为进行了研究在pH 7.4和5，观察持续和pH依赖性的药物释放曲线。在体外细胞毒性或空白NZF @白蛋白纳米粒，游离DOX，和NZF @ ALB-Dox的纳米颗粒对HeLa细胞（细胞系）的抗癌活性也通过MTT法检测。得到的结果表明，这种可扩展的基于鸡蛋蛋白磁性纳米制剂适合靶向给药的应用。因此，本研究可能是基于白蛋白纳米载体的设计和开发用于生物医学应用，如抗癌药物的靶向和控制下交付的进步是非常有用的。

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