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首页> 外文期刊>New Journal of Chemistry >Polymeric nanoparticles-based multi-functional coatings on NiTi alloy with nickel ion release control, cytocompatibility, and antibacterial performance
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Polymeric nanoparticles-based multi-functional coatings on NiTi alloy with nickel ion release control, cytocompatibility, and antibacterial performance

机译：基于聚合物纳米颗粒的NITI合金基于多功能涂层，具有镍离子释放对照，细胞组合和抗菌性能

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摘要

Nickel-titanium alloy (NiTi alloy) has recently received an increasing amount of attention. However, the release of toxic nickel ions and the threat of implant infections has limited its clinical applications. Thus, we report a promising copolymer coating with excellent nickel ion (Ni2+) inhibition release, cytocompatibility, and antimicrobial properties to solve these safety issues involving NiTi alloy implantation. Quaternized copolymers poly (7-hydroxy-4-methylcoumarin methacrylate-co-2-hydroxyethyl methacrylate-co-2-(dimethylamino)ethyl methacrylate) (PCHD-Q) with many hydroxyl and tertiary amine groups were first synthesized, self-assembled into nanoparticles, and then deposited on NiTi substrate through electrodeposition. After UV irradiation, scanning electron microscopy (SEM) images revealed that homogeneous, continuous, and dense coatings were obtained. The coatings showed good improvement of protective behavior for the NiTi alloy in an in vitro environment and could significantly decrease the release of Ni2+ through physical barriers and physical adsorption, which could obviously reduce cytotoxicity inducing by Ni2+. According to in vitro cell viability and antibacterial tests, the quaternized coating materials not only provided a relatively stable biointerface for cell adhesion, spreading and growth, but also obtained excellent antimicrobial activity for the bare NiTi alloy against S. aureus and E. coli. These results suggested that our coatings materials have the potential for improving the safety and success rate of NiTi-based implantations.
机译：镍 - 钛合金（NITI合金）最近收到了越来越大的关注。然而，释放有毒镍离子和植入物感染的威胁已经限制了其临床应用。因此，我们报告了具有优异的镍离子（Ni2 +）抑制释放，细胞组织性和抗微生物性质的有前途的共聚物涂层，以解决涉及Niti合金植入的这些安全问题。首先合成季铵化共聚物聚（7-羟基-4-甲基丙林甲基丙烯酸酯-CO-甲基丙烯酸酯-CO-2-（二甲基氨基）乙酯）（PCHD-Q），具有许多羟基和叔胺基团，自组装成纳米颗粒，然后通过电沉积沉积在Niti衬底上。在UV照射后，扫描电子显微镜（SEM）图像显示，获得均匀，连续和致密的涂层。涂层表明，在体外环境中对NITI合金的保护行为良好，可以通过物理屏障和物理吸附显着降低Ni2 +的释放，这可以明显降低Ni2 +的细胞毒性。根据体外细胞活力和抗菌试验，季铵化涂层材料不仅提供了用于细胞粘附，扩散和生长的相对稳定的生物缠结，而且还获得了针对金黄色葡萄球菌和大肠杆菌的裸NITI合金的优异抗微生物活性。这些结果表明，我们的涂料材料具有提高Niti植入的安全性和成功率的可能性。

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  • 来源
    《New Journal of Chemistry》 |2019年第3期|共11页
  • 作者

    Meng Long; Wu Yunan; Pan Kai; Zhu Ye; Li Xiaojie; Wei Wei; Liu Xiaoya;

  • 作者单位

    Jiangnan Univ Key Lab Synthet &

    Biol Colloids Minist Educ Sch Chem &

    Mat Engn Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Key Lab Synthet &

    Biol Colloids Minist Educ Sch Chem &

    Mat Engn Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Key Lab Synthet &

    Biol Colloids Minist Educ Sch Chem &

    Mat Engn Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Key Lab Synthet &

    Biol Colloids Minist Educ Sch Chem &

    Mat Engn Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Key Lab Synthet &

    Biol Colloids Minist Educ Sch Chem &

    Mat Engn Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Key Lab Synthet &

    Biol Colloids Minist Educ Sch Chem &

    Mat Engn Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Key Lab Synthet &

    Biol Colloids Minist Educ Sch Chem &

    Mat Engn Wuxi 214122 Jiangsu Peoples R China;

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