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首页> 外文期刊>Nucleic Acids Research >Identification of discrete classes of small nucleolar RNA featuring different ends and RNA binding protein dependency
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Identification of discrete classes of small nucleolar RNA featuring different ends and RNA binding protein dependency

机译：鉴定不同末端的小核仁RNA的离散类别和RNA结合蛋白依赖性

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摘要

Small nucleolar RNAs (snoRNAs) are among the first discovered and most extensively studied group of small non-coding RNA. However, most studies focused on a small subset of snoRNAs that guide the modification of ribosomal RNA. In this study, we annotated the expression pattern of all box C/D snoRNAs in normal and cancer cell lines independent of their functions. The results indicate that C/D snoRNAs are expressed as two distinct forms differing in their ends with respect to boxes C and D and in their terminal stem length. Both forms are overexpressed in cancer cell lines but display a conserved end distribution. Surprisingly, the long forms are more dependent than the short forms on the expression of the core snoRNP protein NOP58, thought to be essential for C/D snoRNA production. In contrast, a subset of short forms are dependent on the splicing factor RB-FOX2. Analysis of the potential secondary structure of both forms indicates that the k-turn motif required for binding of NOP58 is less stable in short forms which are thus less likely to mature into a canonical snoRNP. Taken together the data suggest that C/D snoRNAs are divided into at least two groups with distinct maturation and functional preferences.
机译：小核仁RNA（Snornas）是第一次发现和最广泛研究的小型非编码RNA组中。然而，大多数研究专注于指导核糖体RNA的修饰的小组的小型子集。在这项研究中，我们向正常和癌细胞系中的所有箱C / D翼游伤的表达模式注释了独立于其功能。结果表明，C / D Snornas表示为在其端部的两端不同的不同形式，相对于盒C和D以及其端子杆长度。两种形式在癌细胞系中过表达，但显示了保守的最终分布。令人惊讶的是，长形式更依赖于核心Snornp蛋白NOP58表达的短片，认为是C / D Snorna生产必不可少的。相反，短片子集依赖于剪接因子RB-Fox2。两种形式的潜在二级结构的分析表明，NOP58结合所需的K转圈基序在短的形式中稳定，因此不太可能成熟成典型的Snornp。占据数据表明，C / D Snornas分为至少两组，具有不同的成熟和功能偏好。

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