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首页> 外文期刊>Life sciences >Acceleration of wound healing activity with syringic acid in streptozotocin induced diabetic rats
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Acceleration of wound healing activity with syringic acid in streptozotocin induced diabetic rats

机译：链脲佐菌素诱导糖尿病大鼠注射酸的伤口愈合活性加速

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摘要

Impaired wound healing is a serious concern of uncontrolled hyperglycemia that can lead to gangrene, and even death. There is an urgent need to look for better alternative therapy because of the undesirable side effects of currently available synthetic drugs in the market. Syringic acid (SA) is a natural phenolic compound abundantly available in edible fruits and plants. In this study, wound healing activities of 2.5% and 5.0% SA were evaluated in type 2 diabetic rats using incisional wound model. SA-treated diabetic wounds showed faster rate of wound closure and epithelization with enhanced contents of hydroxyproline and protein compared to diabetic wounds. SA effectively prevents alterations in blood glucose levels, serum insulin and dyslipidemia in diabetic wound rats. The SA-treated diabetic wounds after 14 days of treatment demonstrated inhibition of pro-inflammatory response (NF-kappa B p65, TNF-alpha, IL-1 beta, IL-8 and IL-2) with improvement in anti-inflammatory response (IL-10), inhibited the elevated oxidative stress and decreased the concentrations of matrix metalloproteinases (MMP-2, -8 and -9) and increased the concentrations of TIMP-1 & TIMP- 2. Furthermore, the diabetic wounds were presented with an increase in expression of CD 31 and 68, growth factors (TGF-beta 1, collagen-I and alpha-SMA and VEGF) with significant improvement in collagen deposition, re-epithelialization and complete skin structure as revealed by histological analysis after treatment of diabetic wounds with SA for 14 days. Hence, the results of this study designate that SA significantly improves wound healing in diabetic rats and could be used as a potential therapy for treatment of diabetic wounds.
机译：受损的伤口愈合是一种严重关注的不受控制的高血糖，可以导致坏疽，甚至死亡。由于目前可用的合成药物在市场上的不良副作用，迫切需要寻找更好的替代治疗。注射酸（SA）是在食用菌和植物中大量提供的天然酚类化合物。在本研究中，使用切口伤口模型在2型糖尿病大鼠中评估2.5％和5.0％SA的伤口愈合活性。与糖尿病伤口相比，SA治疗的糖尿病伤口显示出更快的裂口闭合和上皮，与羟脯氨酸和蛋白质的增强含量。 SA有效地防止糖尿病伤口大鼠血糖水平，血清胰岛素和血脂血症的改变。治疗14天后的SA治疗的糖尿病伤口证明抑制促炎反应（NF-Kappa B P65，TNF-α，IL-1β，IL-8和IL-2），改善抗炎反应（ IL-10）抑制氧化胁迫升高并降低了基质金属蛋白酶（MMP-2，-8和-9）的浓度，并增加了TIMP-1和TIMP-2的浓度。此外，糖尿病伤口均被提出CD 31和68，生长因子（TGF-β1，胶原-I和α-SMA和VEGF）的表达增加，具有显着改善的胶原沉积，重新上皮和完全的皮肤结构，如组织学分析在治疗糖尿病后伤口14天。因此，本研究的结果指出SA显着改善糖尿病大鼠的伤口愈合，并且可以用作治疗糖尿病伤口的潜在疗法。

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  • 来源
    《Life sciences》 |2019年第2019期|共12页
  • 作者

    Ren Jia; Yang Mengjie; Xu Fengyang; Chen Juwu; Ma Shengli;

  • 作者单位

    Zhengzhou Univ Affiliated Hosp 1 Dept Emergency Zhengzhou 450052 Henan Peoples R China;

    Chinese Ctr Dis Control &

    Prevent Natl Inst Viral Dis Control &

    Prevent Beijing 102206 Peoples R;

    Zhengzhou Univ Affiliated Hosp 1 Dept Emergency Zhengzhou 450052 Henan Peoples R China;

    Zhengzhou Univ Affiliated Hosp 1 Dept Emergency Zhengzhou 450052 Henan Peoples R China;

    Zhengzhou Univ Affiliated Hosp 1 Dept Emergency Zhengzhou 450052 Henan Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医药、卫生;
  • 关键词

    Type 2 diabetes; Diabetic wound healing; Syringic acid; Wistar rats;

    机译：2型糖尿病;糖尿病伤口愈合;注射酸;Wistar大鼠;

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