Binge ethanol and MDMA combination exacerbates HSP27 and Trx-1 (biomarkers of toxic cardiac effects) expression in right ventricle

Navarro-Zaragoza Javier; Ros-Simo Clara; Milanes Maria-Victoria; Valverde Olga; Laorden Maria-Luisa

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Binge ethanol and MDMA combination exacerbates HSP27 and Trx-1 (biomarkers of toxic cardiac effects) expression in right ventricle

机译：乙醇和MDMA组合加剧了右心室的HSP27和TRX-1（有毒心脏效应的生物标志物）表达

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Aims: Oxidative stress caused by exposure to drugs of abuse such as ethanol or 3, 4 methylenedioxymethamphetamine (MDMA) may derive from direct or indirect effects in many organs including the heart. The aim of the present work was to evaluate cardiac sympathetic activity and the expression and activation of two antioxidant proteins: heat shock protein27 (HSP27) and thioredoxin-1 (Trx-1) after voluntary binge ethanol consumption, alone and in combination with MDMA.

机译：目的：暴露于诸如乙醇或3,4甲基二氧基戊酰胺（MDMA）的滥用药物引起的氧化应激可能导致包括心脏的许多器官的直接或间接影响。本作本作的目的是评估心脏交感神经活性和两种抗氧化蛋白的表达和活化：热休克蛋白27（HSP27）和硫氧嘧啶-1（TRX-1）单独和与MDMA组合组合。

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来源
《Life sciences》 |2019年第2019期|共8页
作者
Navarro-Zaragoza Javier; Ros-Simo Clara; Milanes Maria-Victoria; Valverde Olga; Laorden Maria-Luisa;
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作者单位

Univ Murcia Fac Med Dept Pharmacol Murcia Spain;

Univ Pompeu Fabra GRNC Barcelona Spain;

Univ Murcia Fac Med Dept Pharmacol Murcia Spain;

Univ Pompeu Fabra GRNC Barcelona Spain;

Univ Murcia Fac Med Dept Pharmacol Murcia Spain;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Heat shock protein 27; Thioredoxin-1; Right ventricle; Binge ethanol; MDMA;

机译：热休克蛋白27;硫昔昔林-1;右心室;泪味乙醇;MDMA;

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1. Binge ethanol and MDMA combination exacerbates HSP27 and Trx-1 (biomarkers of toxic cardiac effects) expression in right ventricle [J] . Navarro-Zaragoza Javier, Ros-Simo Clara, Milanes Maria-Victoria, Life sciences . 2019,第期

机译：乙醇和MDMA组合加剧了右心室的HSP27和TRX-1（有毒心脏效应的生物标志物）表达
2. Behavioural and neuroinflammatory effects of the combination of binge ethanol and MDMA in mice [J] . Clara Ros-Simó, Jessica Ruiz-Medina, Olga Valverde Psychopharmacology . 2012,第3期

机译：狂饮乙醇和摇头丸联合在小鼠中的行为和神经炎症作用
3. Chronic exposure to ethanol exacerbates MDMA-induced hyperthermia and exposes liver to severe MDMA-induced toxicity in CD1 mice. [J] . Pontes H, Duarte JA, de-Pinho PG, Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems . 2008,第1a3期

机译：慢性乙醇暴露会加剧MDMA诱导的体温过高，并使肝脏在CD1小鼠中暴露于严重的MDMA诱导的毒性。
4. Discovery of Biomarkers for Hexachlorobenzene Toxicity Using Population Based Methods on Gene Expression Data [C] . Cem Meydan, Alper Kuecuekural, Deniz Yoeruekoglu, Pattern Recognition in Bioinformatics . 2008

机译：基于基因表达数据的人群方法发现六氯苯毒性生物标志物
5. Disruption of the discriminative stimulus effects of (+)-3,4-methylenedioxymethamphetamine (MDMA) by (+,-)-MDMA neurotoxicity: Protection by fluoxetine. [D] . Virden, Thomas Barnes, III. 1998

机译：（+，-）-MDMA神经毒性破坏（+）-3,4-亚甲二氧基甲基苯丙胺（MDMA）的歧视性刺激作用：氟西汀的保护。
6. Correction: Binge Ethanol and MDMA Combination Exacerbates Toxic Cardiac Effects by Inducing Cellular Stress [O] . Javier Navarro-Zaragoza, Clara Ros-Simó, María-Victoria Milanés, -1

机译：校正：大量的乙醇和MDMA组合通过诱导细胞应激而加剧毒性心脏效应
7. Correction: Binge Ethanol and MDMA Combination Exacerbates Toxic Cardiac Effects by Inducing Cellular Stress. [O] . Javier Navarro-Zaragoza, Clara Ros-Simó, María-Victoria Milanés, 2015

机译：校正：Binge乙醇和mDma组合通过诱导细胞应激加剧有毒心脏病的影响。
8. Biomarkers of Exposure to Toxic Substances. Volume 2: Genomics: Unique Patterns of Differential Gene Expression and Pathway Perturbation Resulting from Exposure to Nephrotoxins with Regional Specific Toxicity [R] . 2009

机译：接触有毒物质的生物标志物。第2卷：基因组学：由于暴露于具有区域特异性毒性的肾毒素而导致的差异基因表达和途径扰动的独特模式

Binge ethanol and MDMA combination exacerbates HSP27 and Trx-1 (biomarkers of toxic cardiac effects) expression in right ventricle

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