KLF4 sensitizes the colon cancer cell HCT-15 to cisplatin by altering the expression of HMGB1 and hTERT

Yadav Suresh Singh; Kumar Manoj; Varshney Akhil; Yadava Pramod Kumar

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KLF4 sensitizes the colon cancer cell HCT-15 to cisplatin by altering the expression of HMGB1 and hTERT

机译：KLF4通过改变HMGB1和HTERT的表达来敏感结肠癌细胞HCT-15至顺铂

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Aims: Insensitivity of cancer cells to therapeutic drugs is the most daunting challenge in cancer treatment. The mechanism of developing chemo-resistance is only partly understood to date. In continuation of some earlier reports, we hypothesize that KLF4, a key transcription factors that also has a crucial role in maintaining the stemness in cancer cells, may offer a basis for chemo-resistance.

机译：目的：癌细胞对治疗药物的不敏感性是癌症治疗中最令人生畏的挑战。迄今为止，显影化学抗性的机理仅部分地理解。在延续一些早期的报告中，我们假设KLF4，一种关键转录因子，在维持癌细胞的茎干方面也具有至关重要的作用，可以为化学抗性提供依据。

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来源
《Life sciences》 |2019年第2019期|共8页
作者
Yadav Suresh Singh; Kumar Manoj; Varshney Akhil; Yadava Pramod Kumar;
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作者单位

Weizmann Inst Sci Herzl St 234 IL-76100 Rehovot Israel;

Jawaharlal Nehru Univ Sch Life Sci Appl Mol Biol Lab New Delhi 110067 India;

Univ Virginia Ctr Adv Vis Sci 415 Lane Rd Charlottesville VA 22908 USA;

Jawaharlal Nehru Univ Sch Life Sci Appl Mol Biol Lab New Delhi 110067 India;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
KLF4; Cisplatin; And chemo-resistance;

机译：KLF4;顺铂;和化学抗性;

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专利

1. KLF4 sensitizes the colon cancer cell HCT-15 to cisplatin by altering the expression of HMGB1 and hTERT [J] . Yadav Suresh Singh, Kumar Manoj, Varshney Akhil, Life sciences . 2019,第期

机译：KLF4通过改变HMGB1和HTERT的表达来敏感结肠癌细胞HCT-15至顺铂
2. NAC1 modulates sensitivity of ovarian cancer cells to cisplatin by altering the HMGB1-mediated autophagic response [J] . Y Zhang, Y Cheng, X Ren, Oncogene . 2012,第8期

机译：NaC1通过改变HMGB1介导的自噬反应来调节卵巢癌细胞对顺铂的敏感性
3. Up-regulation of hTERT expression by low-dose cisplatin contributes to chemotherapy resistance in human hepatocellular cancer cells. [J] . Guo XL, Ma NN, Zhou FG, Oncology reports . 2009,第3期

机译：小剂量顺铂上调hTERT表达有助于人类肝癌细胞的化疗耐药性。
4. Modulation of COX2 and hTERT expression by Photodynamic Therapy in human colon cancer cells [C] . Christine YOW Li Mm Ngan, Ellie CHU Shihng Meir World congress of the International Photodynamic Association . 2009

机译：光动力疗法对人结肠癌细胞COX2和hTERT表达的调节
5. The effects of a purified B-group soyasaponin fraction on the proliferation, cell cycle progression and induction of macroautophagy in HCT-15 human colon adenocarcinoma cells. [D] . Ellington, Allison Ann. 2005

机译：纯化的B组大豆皂苷组分对HCT-15人结肠腺癌细胞增殖，细胞周期进程和诱导巨自噬的影响。
6. Reduction of Orc6 Expression Sensitizes Human Colon Cancer Cells to 5-Fluorouracil and Cisplatin [O] . Elaine J. Gavin, Bo Song, Yuan Wang, 2008

机译：Orc6表达的减少使人类结肠癌细胞对5-氟尿嘧啶和顺铂敏感。
7. hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitizes cervical cancer cells to a low dose of cisplatin [O] . Mitsuhiro Nakamura, Satoru Kyo, Taro Kanaya, 2003

机译：MCP-1的基于HTERT-启动子的肿瘤特异性表达有效地使宫颈癌细胞敏感到低剂量的顺铂

KLF4 sensitizes the colon cancer cell HCT-15 to cisplatin by altering the expression of HMGB1 and hTERT

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