Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPAR gamma-NF-kappa B signaling pathway in rat vascular smooth muscle cells

Xu Li; Liu Jun-tian; Li Kai; Wang Sheng-yu; Xu Shouzhu

首页> 外文期刊>Life sciences >Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPAR gamma-NF-kappa B signaling pathway in rat vascular smooth muscle cells

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Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPAR gamma-NF-kappa B signaling pathway in rat vascular smooth muscle cells

机译：Genistein通过ER-P38 / ERK1 / 2-PPARγ-NF-Kappa B信号通路在大鼠血管平滑肌细胞中抑制Ang II诱导的CRP和MMP-9代。

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Aims: C-reactive protein (CRP) and matrix metalloproteinase (MMP)-9 are involved in the inflammation of atherosclerosis lesions. Genistein (Gen) has been demonstrated to exert beneficial effect on the cardiovascular system. However, it remains unclear whether Gen produces anti-inflammatory effect in vascular smooth muscle cells (VSMCs). Therefore, we investigated the effects of Gen on CRP and MMP-9 expressions induced by angiotensin (Ang) II in VSMCs and the related molecular mechanism.

机译：目的：C反应蛋白（CRP）和基质金属蛋白酶（MMP）-9参与动脉粥样硬化病变的炎症。已经证明了Genistein（Gen）对心血管系统产生了有益作用。然而，仍然不清楚Gen是否在血管平滑肌细胞（VSMC）中产生抗炎作用。因此，我们研究了基因植入（Ang）II在VSMC和相关分子机制中诱导的CRP和MMP-9表达的影响。

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来源
《Life sciences》 |2019年第2019期|共7页
作者
Xu Li; Liu Jun-tian; Li Kai; Wang Sheng-yu; Xu Shouzhu;
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作者单位

Xi An Jiao Tong Univ Sch Med Dept Pharmacol 76 West Yanta Rd Postbox 58 Xian 710061 Shaanxi;

Xi An Jiao Tong Univ Sch Med Dept Pharmacol 76 West Yanta Rd Postbox 58 Xian 710061 Shaanxi;

Xian Med Univ Dept Cardiol Xian 710021 Shaanxi Peoples R China;

Xian Med Univ Affiliated Hosp 1 Dept Intens Care Unit Xian 710077 Shaanxi Peoples R China;

Xi An Jiao Tong Univ Sch Med Dept Pharmacol 76 West Yanta Rd Postbox 58 Xian 710061 Shaanxi;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Genistein; C-reactive protein; Matrix metalloproteinase 9; Angiotensin II; Vascular smooth muscle cells; Atherosclerosis; Inflammation;

机译：Genistein;C-反应蛋白;基质金属蛋白酶9;血管紧张素II;血管平滑肌细胞;动脉粥样硬化;炎症;

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1. Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPAR gamma-NF-kappa B signaling pathway in rat vascular smooth muscle cells [J] . Xu Li, Liu Jun-tian, Li Kai, Life sciences . 2019,第期

机译：Genistein通过ER-P38 / ERK1 / 2-PPARγ-NF-Kappa B信号通路在大鼠血管平滑肌细胞中抑制Ang II诱导的CRP和MMP-9代。
2. Eplerenone inhibits aldosterone-induced CRP generation in rat vascular smooth muscle cells by regulating the MR-ROS-ERK1/2 signal pathway: [J] . Xiaolu Zhang, Juntian Liu, Xiaoming Pang, European Journal of Inflammation . 2017,第3期

机译：依普利农通过调节MR-ROS-ERK1 / 2信号通路抑制醛固酮诱导的大鼠血管平滑肌细胞CRP生成：
3. Role of Ras/PKCzeta/MEK/ERK1/2 signaling pathway in angiotensin II-induced vascular smooth muscle cell proliferation. [J] . Zhao Y, Liu J, Li L, Regulatory peptides. . 2005,第1期

机译：Ras / PKCzeta / MEK / ERK1 / 2信号通路在血管紧张素II诱导的血管平滑肌细胞增殖中的作用。
4. Shear stress-dependent vascular smooth muscle cell migration: regulation by tyrosine kinase signaling pathways [C] . Shu Q. Liu, Lin Zhong, Jeremy Goldman Bioengineering Conference . 2001

机译：剪切应力依赖性血管平滑肌细胞迁移：由酪氨酸激酶信号传导途径调节
5. CD40 signaling pathways in the induction of monocyte/macrophage/vascular smooth muscle cell pro-inflammatory function. [D] . Mukundan, Lata. 2004

机译：CD40信号通路在诱导单核细胞/巨噬细胞/血管平滑肌细胞促炎功能中的作用。
6. Cortistatin exerts antiproliferation and antimigration effects in vascular smooth muscle cells stimulated by Ang II through suppressing ERK1/2 p38 MAPK JNK and ERK5 signaling pathways [O] . Ying Wang, Xin Zhang, Lei Gao, 2019

机译：皮质抑素通过抑制ERK1 / 2p38 MAPKJNK和ERK5信号通路在Ang II刺激的血管平滑肌细胞中发挥抗增殖和抗迁移作用
7. Tanshinone IIA Can Inhibit Angiotensin II-Induced Proliferation and Autophagy of Vascular Smooth Muscle Cells via Regulating the MAPK Signaling Pathway [O] . Jingping Lu, Jinjun Shan, Ning Liu, 2019

机译：丹参酮IIa可以抑制血管紧张素II诱导的血管平滑肌细胞的增殖和自噬，通过调节MAPK信号通路来抑制血管平滑肌细胞

Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPAR gamma-NF-kappa B signaling pathway in rat vascular smooth muscle cells

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