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Ligands for cannabinoid receptors, promising anticancer agents

机译：大麻素受体的配体，有前途的抗癌剂

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摘要

Cannabinoid compounds are unique to cannabis and provide some interesting biological properties. These compounds along with endocannabinoids, a group of neuromodulator compounds in the body especially in brain, express their effects by activation of G-protein-coupled cannabinoid receptors, CB1 and CB2. There are several physiological properties attributed to the endocannabinoids including pain relief, enhancement of appetite, blood pressure lowering during shock, embryonic development, and blocking of working memory. On the other hand, activation of endocannabinoid system may be suppresses evolution and progression of several types of cancer. According to the results of recent studies, CB receptors are over-expressed in cancer cell lines and application of multiple cannabinoid or cannabis-derived compounds reduce tumor size through decrease of cell proliferation or induction of cell cycle arrest and apoptosis along with desirable effect on decrease of tumor evoked pain. Therefore, modulation of endocannabinoid system by inhibition of fatty acid amide hydrolase (FAAH), the enzyme, which metabolized endocannabinoids, or application of multiple cannabinoid or cannabis-derived compounds, may be appropriate for the treatment of several cancer subtypes. This review focuses on how cannabinoid affect different types of cancers. (C) 2016 Elsevier Inc. All rights reserved.
机译：大麻化合物对大麻是独特的，并提供一些有趣的生物学性质。这些化合物以及内胆蛋白化合物，一组尤其在脑中的一组神经调节剂化合物，通过激活G蛋白偶联的大麻素受体，CB1和CB2表达它们的作用。归因于内胆碱的生理特性，包括疼痛缓解，增强食欲，缓冲期间降低血压，胚胎发育和堵塞工作记忆。另一方面，Endocannabinoid系统的激活可以抑制几种类型癌症的演化和进展。根据近期研究的结果，Cb受体在癌细胞系中过于表达，并在多个大麻素或大麻衍生的化合物的应用降低肿瘤大小，降低细胞增殖或诱导细胞周期停滞和细胞凋亡以及对减少的理想效果肿瘤诱发疼痛。因此，通过抑制脂肪酸酰胺水解酶（FAAH），酶，酶的调节，即代谢的内凸蛋白或多个大麻素或大麻衍生的化合物的酶可能适用于治疗几种癌症亚型。本综述重点是大麻素如何影响不同类型的癌症。 （c）2016 Elsevier Inc.保留所有权利。

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