Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells

Silva Sara M.; Martinho Ana; Moreno Ivo; Silvestre Samuel; Granadeiro Luiza Breitenfeld; Alves Gilberto; Duarte Ana Paula; Domingues Fernanda; Gallardo Eugenia

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Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells

机译：金丝桃粒子提取物及其主要生物活性化合物对肝细胞中CYP1A2和CYP2D6的细胞毒性和表达的影响

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Aims: Hypericum perforatum (H. perforatum) is one of the most used medicinal plants. However, it has been associated with relevant interactions with several drugs. This situation is probably mediated by cytochrome P450 enzymes (CYP450), namely the 1A2 (CYP1A2) and 2D6 (CYP2D6) isoforms This study aims to assess the cytotoxic and CYP1A2 and CYP2D6 inductive and/or inhibitory effects of a H. perforatum extract and its main bioactive components in hepatic cell lines.

机译：目的：金丝桃属植物（H.Perforatum）是最常用的药用植物之一。然而，它与与几种药物的相关相互作用有关。这种情况可能由细胞色素P450酶（CYP450）介导，即1A2（CYP1A2）和2D6（CYP2D6）同种型，本研究旨在评估H.Poplum提取物的细胞毒性和CYP1A2和CYP2D6感应和/或抑制作用肝细胞系中的主要生物活性成分。

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来源
《Life sciences》 |2016年第1期|共7页
作者
Silva Sara M.; Martinho Ana; Moreno Ivo; Silvestre Samuel; Granadeiro Luiza Breitenfeld; Alves Gilberto; Duarte Ana Paula; Domingues Fernanda; Gallardo Eugenia;
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作者单位

Univ Beira Interior CICS UBI Hlth Sci Res Ctr P-6200506 Covilha Portugal;

Univ Beira Interior CICS UBI Hlth Sci Res Ctr P-6200506 Covilha Portugal;

Univ Beira Interior CICS UBI Hlth Sci Res Ctr P-6200506 Covilha Portugal;

Univ Beira Interior CICS UBI Hlth Sci Res Ctr P-6200506 Covilha Portugal;

Univ Beira Interior CICS UBI Hlth Sci Res Ctr P-6200506 Covilha Portugal;

Univ Beira Interior CICS UBI Hlth Sci Res Ctr P-6200506 Covilha Portugal;

Univ Beira Interior CICS UBI Hlth Sci Res Ctr P-6200506 Covilha Portugal;

Univ Beira Interior CICS UBI Hlth Sci Res Ctr P-6200506 Covilha Portugal;

Univ Beira Interior CICS UBI Hlth Sci Res Ctr P-6200506 Covilha Portugal;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Hypericum perforatum; Hypericin; Hyperforin; CYP1A2; CYP2D6; Hepatic cells; Herb-drug interactions;

机译：金刚素穿孔;金刚素;高素蛋白;CYP1A2;CYP2D6;肝细胞;草药相互作用;

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专利

1. Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells [J] . Silva Sara M., Martinho Ana, Moreno Ivo, Life sciences . 2016,第1期

机译：金丝桃粒子提取物及其主要生物活性化合物对肝细胞中CYP1A2和CYP2D6的细胞毒性和表达的影响
2. Effects of Hypericum perforatum hydroalcoholic extract, hypericin, and hyperforin on cytotoxicity and CYP3A4 mRNA expression in hepatic cell lines: a comparative study [J] . Martinho Ana, Silva Sara M., Garcia Sara, Medicinal chemistry research: an international journal for rapid communications on design and mechanisms of action of biologically active agents . 2016,第12期

机译：贯叶连翘水乙醇提取物，金丝桃素和金丝桃素对肝细胞毒性和CYP3A4 mRNA表达的影响
3. Co-extracted bioactive compounds in Capsicum fruit extracts prevent the cytotoxic effects of capsaicin on B104 neuroblastoma cells [J] . Viktorija Maksimova, Liljana K. Gudeva, Karen Nieber, Revista Brasileira de Farmacognosia . 2016,第6期

机译：辣椒果实提取物中的共提取生物活性化合物可防止辣椒素对B104神经母细胞瘤细胞的细胞毒性作用
4. Fractionation of the Hypericum perforatum L. extract - PMF, and PDT effects of the fractions against HL-60 leukemic cells [C] . M. Tsontou, H. Dimitriou, G. Filippidis, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI; Progress in Biomedical Optics and Imaging; vol.8 no.4; Proceedings of SPIE-The International Society for Optical Engineering; vol.6427 . 2007

机译：贯叶连翘提取物-PMF的分级分离和PDT对HL-60白血病细胞的作用
5. Elucidation of anti -inflammatory constituents in Hypericum perforatum extracts and delineation of mechanisms of anti-inflammatory activity in RAW 264.7 mouse macrophages [D] . Hammer, Kimberly Dawn Petry. 2008

机译：贯叶连翘提取物中抗炎成分的阐明和RAW 264.7小鼠巨噬细胞中抗炎活性机制的描述
6. Evaluation of the Light-Sensitive Cytotoxicity of Hypericum perforatum Extracts Fractions and Pure Compounds [O] . Laura A. Schmitt, Yi Liu, Patricia A. Murphy, -1

机译：贯叶连翘提取物级分和纯化合物的光敏感细胞毒性评估
7. Co-extracted bioactive compounds in Capsicum fruit extracts prevent the cytotoxic effects of capsaicin on B104 neuroblastoma cells [O] . Viktorija Maksimova, Liljana K. Gudeva, Rubin Gulaboski, 2016

机译：辣椒果实提取物中共同提取的生物活性化合物可防止辣椒素对B104神经母细胞瘤细胞的细胞毒作用

Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells

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