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Diets with different lipid contents do not modify the neuronal membrane lipid raft profile in a scrapie murine model

机译:具有不同脂质含量的饮食不会在Scrapie鼠模型中修饰神经元膜脂筏谱

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摘要

In Transmissible Spongiform Encephalopathies (TSEs), the localization of the prion protein in the neuronal membrane lipid rafts (LR) seems to play a role in sustaining the protein misfolding. Changes in membrane properties, due to altered lipid composition, affect their organization and interaction between lipids and protein therein, and consequently also membrane resident protein functionality; dietary polyunsaturated fatty acids (PUFAs), gangliosides and cholesterol seem to influence these processes.
机译:在传式的海绵状脑病(TSES)中,神经膜脂筏(LR)中朊病毒蛋白的定位似乎在维持蛋白质错误折叠时发挥作用。 由于脂质组合物改变,膜特性的变化影响它们的组织和其中脂质和蛋白质之间的相互作用,因此也是膜常住蛋白质功能; 膳食多不饱和脂肪酸(PUFAs),神经节苷脂和胆固醇似乎影响了这些过程。

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