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首页> 外文期刊>Life sciences >Cell signaling in NMDA preconditioning and neuroprotection in convulsions induced by quinolinic acid.
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Cell signaling in NMDA preconditioning and neuroprotection in convulsions induced by quinolinic acid.

机译：喹啉酸诱导的NMDA预处理和神经保护中的细胞信号传导。

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摘要

The search for novel, less invasive therapeutic strategies to treat neurodegenerative diseases has stimulated scientists to investigate the mechanisms involved in preconditioning. Preconditioning has been report to occur in many organs and tissues. In the brain, the modulation of glutamatergic transmission is an important and promising target to the use of effective neuroprotective agents. The glutamatergic excitotoxicity is a factor common to neurodegenerative diseases and acute events such as cerebral ischemia, traumatic brain injury and epilepsy. In this review we focus on the neuroprotection and preconditioning by chemical agents. Specially, chemical preconditioning models using N-methyl-d-aspartate (NMDA) pre-treatment, which has demonstrated to lead to neuroprotection against seizures and damage to neuronal tissue induced by quinolinic acid (QA). Here we attempted to gather important results obtained in the study of cellular and molecular mechanisms involved in NMDA preconditioning and neuroprotection.
机译：寻找新颖，较少的侵袭性治疗神经变性疾病的侵袭性策略已经刺激了科学家们调查预处理所涉及的机制。预处理已经报告发生在许多器官和组织中。在大脑中，对谷氨酸盐传输的调节是使用有效神经保护剂的重要和有前途的目标。谷氨酸胶苷株是神经退行性疾病和急性事件常见的因素，如脑缺血，创伤性脑损伤和癫痫。在这篇综述中，我们专注于化学试剂的神经保护和预处理。特别地，使用N-甲基-D-天冬氨酸（NMDA）预处理的化学预处理模型已经证明是导致喹啉酸（QA）诱导的神经组织的神经保护作用。在这里，我们试图收集在研究NMDA预处理和神经保护作用的细胞和分子机制研究中获得的重要结果。

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