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首页> 外文期刊>Life sciences >Glioblastoma cells: a heterogeneous and fatal tumor interacting with the parenchyma.
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Glioblastoma cells: a heterogeneous and fatal tumor interacting with the parenchyma.

机译：胶质母细胞：与实质相互作用的异质和致命的肿瘤。

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Glioblastomas (GBMs) are considered to be one of the deadliest human cancers, characterized by a high proliferative rate, aggressive invasiveness and insensitivity to radio- and chemotherapy, as well as a short patient survival period. Moreover, GBMs are among the most vascularized and invasive cancers in humans. Angiogenesis in GBMs is correlated with the grade of malignancy and is inversely correlated with patient survival. One of the first steps in tumor invasions is migration. GBM cells have the ability to infiltrate and disrupt physical barriers such as basement membranes, extracellular matrix and cell junctions. The invasion process includes the overexpression of several members of a super-family of zinc-based proteinases, the Metzincin, in particular a sub-group, metalloproteinases. Another interesting aspect is that, inside the GBM tissue, there are up to 30% of microglia or macrophages. However, little is known about the immune performance and interactions of the microglia with GBMs. These singular properties of GBMs will be described here. A sub-population of cells with stem-like properties may be the source of tumors since, apparently, GBM stem cells (GSCs) are highly resistant to current cancer treatments. These cancer therapies, while killing the majority of tumor cells, ultimately fail in GBM treatment because they do not eliminate GSCs, which survive to regenerate new tumors. Finally, GBM patient prognostic has shown little improvement in decades. In this context, we will discuss how the membrane-acting toxins called cytolysins can be a potential new tool for GBM treatment.
机译：Glioblastomas（GBMS）被认为是最致命的人类癌症之一，其特征在于高增殖率，对无线电和化疗的侵袭性侵袭性和不敏感性，以及短暂的患者存活期。此外，GBMS是人类中最血管化和侵袭性的癌症之一。 GBMS中的血管生成与恶性肿瘤的等级相关，与患者存活率相反。肿瘤入侵中的第一步之一是迁移。 GBM细胞具有渗透和破坏物理屏障，例如基底膜，细胞外基质和细胞连接。侵袭过程包括超表达的锌基蛋白酶的超级族蛋白酶，甲硝素，特别是亚组，金属蛋白酶的过度表达。另一个有趣的方面是，在GBM组织内，占MICROGLIA或巨噬细胞的30​​％。然而，关于MICRIGLIA与GBMS的免疫表现和相互作用很少。这里将描述GBMS的这些奇异性质。具有干燥性质的细胞的亚群可以是肿瘤源，因为显然，GBM干细胞（GSCs）对当前的癌症治疗具有高度抗性。这些癌症疗法，同时杀死大多数肿瘤细胞，最终在GBM治疗中失败，因为它们不会消除GSCs，其存活以再生新肿瘤。最后，GBM患者的预后已经显示出几十年来的改善。在这种情况下，我们将讨论称为Cytolysins的膜的作用毒素是如何成为GBM治疗的潜在新工具。

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