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首页> 外文期刊>Life sciences >mGlu5 receptor deletion reduces relapse to food-seeking and prevents the anti-relapse effects of mGlu5 receptor blockade in mice.
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mGlu5 receptor deletion reduces relapse to food-seeking and prevents the anti-relapse effects of mGlu5 receptor blockade in mice.

机译：MGLU5受体缺失减少了对食品的复发并阻止了MGLU5受体阻滞在小鼠中的抗复制作用。

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AIMS: Convergent data suggest that there is a hyperglutamatergic state that arises during relapse to drug seeking. Blockade of mGlu5 receptors provides one approach to dampening glutamate tone. However, the role of mGlu5 receptors in relapse to food seeking behavior has not been explored extensively and has not been scrutinized using receptor null mice. MAIN METHODS: Wild-type (WT) and mGlu5 receptor knockout (KO) mice were compared under the acquisition of a discriminated operant response maintained by food, during extinction of the response, and during the reinstatement of the response by food and food-associated stimuli. The impact of the mGlu5 receptor antagonist MTEP was investigated. KEY FINDINGS: Acquisition and extinction were not markedly different in WT and KO mice. MTEP decreased response reinstatement in WT mice. This behavioral effect of MTEP was not present in the KO mice, demonstrating the dependence of the effect of MTEP on mGlu5 receptors. As with the effect of MTEP in WT mice, receptor deletion reduced response reinstatement in KO mice. SIGNIFICANCE: This is the first report to evaluate the reinstatement of food-seeking in mGlu5 receptor KO mice. The data reported here add to those in the literature that support a role for mGlu5 receptors in the control of this relapse effect. The data also reinforce the potential utility of mGlu5 receptor antagonists in relapse prevention to food-seeking behaviors.
机译：旨在：收敛数据表明，存在在毒品中发生的过度植根态。阻断MGLU5受体提供一种抑制谷氨酸色调的一种方法。然而，未经广泛的探讨MGLU5受体在复发中的作用，并且尚未使用受体含氟小鼠仔细审查。主要方法：在收购歧视的操作响应期间，在灭绝灭绝期间，在答复期间，在答复期间维持的歧视操作响应，以及在恢复食物和食品相关的响应期间，比较野生型（WT）和MGLU5受体敲除（KO）小鼠。刺激。研究了MGLU5受体拮抗剂MTEP的影响。关键发现：WT和KO小鼠的采集和消灭并不明显不同。 MTEP在WT小鼠中减少了响应恢复。 MTEP的这种行为效应不存在于KO小鼠中，证明了MTEP对MGLU5受体作用的依赖性。与MTEP在WT小鼠中的影响一样，受体缺失在KO小鼠中减少响应恢复。意义：这是第一个评估MGLU5受体KO小鼠中寻求食品的恢复的报告。此处报告的数据增加了那些在控制这种复发效应的控制中支持MGLU5受体的作用的文献中的那些。数据还增强了MGLU5受体拮抗剂在复发预防方面对食品行为的潜在效用。

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