• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Exercise training mitigates aberrant cardiac protein O-GlcNAcylation in streptozotocin-induced diabetic mice
【24h】

Exercise training mitigates aberrant cardiac protein O-GlcNAcylation in streptozotocin-induced diabetic mice

机译：运动训练减轻了糖尿病诱导的糖尿病小鼠中的异常心脏蛋白O-甘氨酸蛋白

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aims: Increased protein O-GlcNAcylation occurs in response to increased availability of glucose and fatty acids and is a hallmark of diabetes. Previous studies have demonstrated an improvement in heart function associated with decreased protein O-GlcNAcylation. Our group has recently demonstrated a capacity for exercise to decrease protein O-GlcNAcylation in the heart of normal mice; however, the impact of such training under diabetic conditions has not been examined. Main methods: Diabetes was induced in mice through injection of streptozotocin. Animals either remained sedentary or were subjected to 6 weeks of swim training protocol. At the end of 6 weeks in vivo cardiac function was assessed and the hearts were harvested for gene expression and Western blotting in relation to O-GlcNAcylation Key findings: Diabetes resulted in elevated blood glucose relative to non-diabetic mice. Relative to the sedentary diabetic group, the rate of relaxation (Tau) was significantly improved in the exercised group. Western blot analysis revealed an increase in protein O-GlcNAcylation in the diabetic group which was reversed through exercise despite persistent hyperglycemia. No change in the expression of O-GlcNAc transferase (OGT) was noted between sedentary and exercised diabetic mice; however an increase in the expression and activity of O-GlcNAcase (OGA) was apparent in the exercised group. Significance: This study demonstrates the potential for exercise training to decrease intracellular protein O-GlcNAcylation in the heart even under conditions of persistent hyperglycemia associated with diabetes. Our results suggest the beneficial effects of regular aerobic exercise extend beyond simple regulation of blood glucose levels. ? 2012 Elsevier Inc.
机译：目的：响应于葡萄糖和脂肪酸的可用性而增加，蛋白质o-glcnacylation的增加，并且是糖尿病的标志。以前的研究表明，与降低的蛋白质O-GlcNacylation相关的心脏功能有所改善。我们的小组最近展示了锻炼能力减少正常小鼠心脏中的蛋白质O-GlcnaCylation;但是，尚未检查这种训练在糖尿病条件下的影响。主要方法：通过注射链脲佐菌素在小鼠中诱导糖尿病。动物仍然久坐不动或经过6周的游泳训练协议。在6周结束时体内心脏功能进行评估，并在与O-GlcNacylation的关键结果相关的基因表达和蛋白质印迹中收获心脏，导致血糖相对于非糖尿病小鼠升高。相对于久坐不动糖尿病组，在运动组中松弛（TAU）显着改善。 Western印迹分析显示，尽管持续的高血糖血症，糖尿病组在糖尿病组中的蛋白质O-GlcnaCyation增加。在久入和患有糖尿病小鼠之间注意到O-GlcNAc转移酶（OGT）表达的变化;然而，在运动组中，O-Glcnacase（OGA）的表达和活性的增加是显而易见的。意义：本研究表明，即使在与糖尿病相关的持续高血糖条件下，甚至在心脏中降低心脏细胞内蛋白质O-Glcnynation的潜力。我们的研究结果表明，常规有氧运动的有益效果超出了血糖水平的简单调节。还是2012年Elsevier Inc.

著录项

  • 来源
    《Life sciences》 |2013年第11期|共7页
  • 作者

    BennettC.E.; JohnsenV.L.; ShearerJ.; BelkeD.D.;

  • 作者单位

    3318B Roger Jackson Center Faculty of Kinesiology University of Calgary 2500 University Drive NW;

    3318B Roger Jackson Center Faculty of Kinesiology University of Calgary 2500 University Drive NW;

    3318B Roger Jackson Center Faculty of Kinesiology University of Calgary 2500 University Drive NW;

    3318B Roger Jackson Center Faculty of Kinesiology University of Calgary 2500 University Drive NW;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医药、卫生;
  • 关键词

    Diabetes; O-GlcNAc transferase; O-GlcNAcase; Swim training;

    机译：糖尿病;O-Glcnac转移酶;O-Glcnacase;游泳训练;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号