Fingolimod (FTY720) attenuates social deficits, learning and memory impairments, neuronal loss and neuroinflammation in the rat model of autism

Wu Hongmei; Wang Xuelai; Gao Jingquan; Liang Shuang; Hao Yanqiu; Sun Caihong; Xia Wei; Cao Yonggang; Wu Lijie

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Fingolimod (FTY720) attenuates social deficits, learning and memory impairments, neuronal loss and neuroinflammation in the rat model of autism

机译：Fingolimod（FTY720）在自闭症大鼠模型中衰减社会赤字，学习和记忆障碍，学习和记忆障碍，神经元丧失和神经炎症

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Aims: To investigate the effect of FTY720 on the valproic acid (VPA) rat model of autism. Main methods: As an animal model of autism, we used intraperitoneal injection of VPA on embryonic day 12.5 in Wistar rats. The pups were given FTY720 orally at doses of 0.25, 0.5 and 1 mg/kg daily from postnatal day 15 to 35. Social behavior, spatial learning and memory were assessed at the end of FTY720 treatment. The histological change, oxidative stress, neuroinflammatory responses, and apoptosis-related proteins in the hippocampus were evaluated.

机译：目的：探讨FTY720对自闭症丙戊酸（VPA）大鼠模型的影响。主要方法：作为自闭症的动物模型，我们在Wistar大鼠中使用腹膜内注射VPA 12.5。从产后第15至35天，每天0.25,0.5和1mg / kg的剂量以0.25,0.5和1 mg / kg给予FTY720。在FTY720治疗结束时评估社会行为，空间学习和记忆。评价了海马中的组织学变化，氧化应激，神经炎性反应和凋亡相关蛋白。

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来源
《Life sciences》 |2017年第2017期|共12页
作者
Wu Hongmei; Wang Xuelai; Gao Jingquan; Liang Shuang; Hao Yanqiu; Sun Caihong; Xia Wei; Cao Yonggang; Wu Lijie;
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作者单位

Harbin Med Univ Sch Publ Hlth Dept Child &

Adolescent Hlth 157 Baojian Rd Harbin 150081;

Harbin Med Univ Sch Publ Hlth Dept Child &

Adolescent Hlth 157 Baojian Rd Harbin 150081;

Harbin Med Univ Daqing Dept Nursing Daqing 163319 Heilongjiang Peoples R China;

Harbin Med Univ Sch Publ Hlth Dept Child &

Adolescent Hlth 157 Baojian Rd Harbin 150081;

Harbin Med Univ Affiliated Hosp 2 Dept Pediat Harbin 150081 Heilongjiang Peoples R China;

Harbin Med Univ Sch Publ Hlth Dept Child &

Adolescent Hlth 157 Baojian Rd Harbin 150081;

Harbin Med Univ Sch Publ Hlth Dept Child &

Adolescent Hlth 157 Baojian Rd Harbin 150081;

Harbin Med Univ Daqing Dept Pharmacol Daqing 163319 Heilongjiang Peoples R China;

Harbin Med Univ Sch Publ Hlth Dept Child &

Adolescent Hlth 157 Baojian Rd Harbin 150081;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Fingolimod (FTY720); Autism spectrum disorder; VPA; Hippocampal cell; Oxidative stress; Neuroinflammatory;

机译：Fingolimod（Fty720）;自闭症谱系障碍;VPA;海马细胞;氧化应激;神经肾性炎症;

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1. Fingolimod (FTY720) attenuates social deficits, learning and memory impairments, neuronal loss and neuroinflammation in the rat model of autism [J] . Wu Hongmei, Wang Xuelai, Gao Jingquan, Life sciences . 2017,第期

机译：Fingolimod（FTY720）在自闭症大鼠模型中衰减社会赤字，学习和记忆障碍，学习和记忆障碍，神经元丧失和神经炎症
2. Motor Impairments Correlate with Social Deficits and Restricted Neuronal Loss in an Environmental Model of Autism [J] . Al Sagheer Tareq, Haida Obelia, Balbous Anais, The international journal of neuropsychopharmacology . 2018,第9期

机译：在自闭症的环境模型中，运动障碍与社交缺陷和受限的神经元丢失相关
3. Dehydroevodiamine.HCl prevents impairment of learning and memory and neuronal loss in rat models of cognitive disturbance. [J] . Park CH, Lee YJ, Lee SH, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2000,第1期

机译：脱氢戊二胺.HCl可预防大鼠认知障碍模型的学习和记忆障碍以及神经元丢失。
4. Is Autism, Attention Deficit Hyperactivity Disorder (ADHD) and Specific Learning Disorder linked to Impaired Emotion Recognition in Primary School Aged Children? [C] . Aliki Economides, Chiara Baiano, Isa Zappullo, IEEE International Conference on Human-Machine Systems . 2020

机译：自闭症，注意力缺陷多动障碍（ADHD）和特定学习障碍是否与小学适龄儿童的情绪认知障碍相关？
5. Pten Loss Increases Microtubule Polymerization Rate: Implications for Neuronal Migration, Dendritic Arborization, and Autism [D] . Getz, Stephanie A 2019

机译：Pten损失增加微管聚合速率：对神经元迁移，树突状树状化和自闭症的影响。
6. Motor Impairments Correlate with Social Deficits and Restricted Neuronal Loss in an Environmental Model of Autism [O] . Tareq Al Sagheer, Obelia Haida, Anais Balbous, -1

机译：在自闭症的环境模型中运动障碍与社交缺陷和受限的神经元丢失相关
7. Dehydroevodiamine·HCl Prevents Impairment of Learning and Memory and Neuronal Loss in Rat Models of Cognitive Disturbance [O] . Cheol Hyoung Park, Young-Jae Lee, Sang Hyung Lee, 2001

机译：脱氢脱硫胺·HCl防止学习和记忆障碍和认知干扰大鼠模型中的神经元损失

Fingolimod (FTY720) attenuates social deficits, learning and memory impairments, neuronal loss and neuroinflammation in the rat model of autism

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