Nicotinamide induces mitochondrial-mediated apoptosis through oxidative stress in human cervical cancer HeLa cells

Feng Yi; Wang Yonghua; Jiang Chengrui; Fang Zishui; Zhang Zhiqiang; Lin Xiaoying; Sun Liwei; Jiang Weiying

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Nicotinamide induces mitochondrial-mediated apoptosis through oxidative stress in human cervical cancer HeLa cells

机译：烟酰胺通过人宫颈癌Hela细胞中的氧化应激诱导线粒体介导的细胞凋亡

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Aims: Nicotinamide participates in energy metabolism and influences cellular redox status and modulates multiple pathways related with both cellular survival and death. Recent studies have shown that it induced proliferation inhibition and apoptosis in many cancer cells. However, little is known about the effects of nicotinamide on human cervical cancer cells. We aimed to evaluate the effects of the indicated concentrations nicotinamide on cell proliferation, apoptosis and redox-related parameters in HeLa cells and investigated the apoptotic mechanism.

机译：目的：烟酰胺参与能量代谢并影响细胞氧化还原状态，并调节与细胞生存和死亡相关的多种途径。最近的研究表明，它诱导了许多癌细胞中的增殖抑制和细胞凋亡。然而，关于烟酰胺对人宫颈癌细胞的影响很少。我们的目标是评估所指示的烟酰胺对HeLa细胞中细胞增殖，细胞凋亡和氧化还原相关参数的影响，并研究了凋亡机制。

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来源
《Life sciences》 |2017年第2017期|共8页
作者
Feng Yi; Wang Yonghua; Jiang Chengrui; Fang Zishui; Zhang Zhiqiang; Lin Xiaoying; Sun Liwei; Jiang Weiying;
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作者单位

74 2nd Zhongshan Rd Guangzhou 510080 Guangdong Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Nicotinamide; Oxidative stress; Mitochondrial apoptotic pathway; Cervical cancer;

机译：烟酰胺;氧化应激;线粒体凋亡途径;宫颈癌;

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专利

1. Nicotinamide induces mitochondrial-mediated apoptosis through oxidative stress in human cervical cancer HeLa cells [J] . Feng Yi, Wang Yonghua, Jiang Chengrui, Life sciences . 2017,第期

机译：烟酰胺通过人宫颈癌Hela细胞中的氧化应激诱导线粒体介导的细胞凋亡
2. Piperazine clubbed with 2-azetidinone derivatives suppresses proliferation, migration and induces apoptosis in human cervical cancer HeLa cells through oxidative stress mediated intrinsic mitochondrial pathway [J] . Khanam Rashmin, Kumar Raj, Hejazi Iram Iqbal, Apoptosis: An international journal on programmed cell death . 2018,第2期

机译：哌嗪杆菌用2-氮丙酮衍生物抑制了通过氧化胁迫介导的内在线粒体途径抑制了人宫颈癌Hela细胞的增殖，迁移和诱导细胞凋亡
3. Melatonin sensitizes human cervical cancer HeLa cells to cisplatin-induced cytotoxicity and apoptosis: effects on oxidative stress and DNA fragmentation [J] . Journal of pineal research . 2016,第1期

机译：褪黑素使人宫颈癌HeLa细胞对顺铂诱导的细胞毒性和细胞凋亡敏感：对氧化应激和DNA片段化的影响
4. Endoplasmic Reticulum Stress Signaling Pathways Is Involved in Trichosanthin-Induced Apoptosis in Human Cervical Cancer Cell Line Hela [C] . Huang Yiling, Huang Liming, You Chengcheng, 2010 4th International Conference on Bioinformatics and Biomedical Engineering . 2010

机译：内质网应激信号通路涉及天花粉蛋白诱导的人宫颈癌细胞株Hela的凋亡。
5. Mechanism of 3,3'-diindolylmethane-induced cell death in human C33A cervical cancer cells: Induction of endoplasmic reticulum stress, apoptosis and the role of growth-arrest and DNA-damage genes [D] . Han, Jing Y. 2009

机译：3,3'-二吲哚基甲烷诱导的人C33A宫颈癌细胞死亡的机制：内质网应激，细胞凋亡以及生长停滞和DNA损伤基因的作用
6. Chemopreventive Effect of β-Cryptoxanthin on Human Cervical Carcinoma (HeLa) Cells Is Modulated through Oxidative Stress-Induced Apoptosis [O] . Enkhtaivan Gansukh, Arti Nile, Iyyakkannu Sivanesan, 2020

机译：β-隐黄质对人宫颈癌（HeLa）细胞的化学预防作用可通过氧化应激诱导的细胞凋亡来调节。
7. Chemopreventive Effect of β-Cryptoxanthin on Human Cervical Carcinoma (HeLa) Cells Is Modulated through Oxidative Stress-Induced Apoptosis [O] . Enkhtaivan Gansukh, Arti Nile, Iyyakkannu Sivanesan, 2019

机译：通过氧化应激诱导的细胞凋亡调节β-乳腺嘌呤对人宫颈癌（HELA）细胞的化学预防效应

Nicotinamide induces mitochondrial-mediated apoptosis through oxidative stress in human cervical cancer HeLa cells

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