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miR-519 suppresses nasopharyngeal carcinoma cell proliferation by targeting oncogene URG4/URGCP

机译：MiR-519通过靶向癌基因URG4 / URGCP来抑制鼻咽癌细胞增殖

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摘要

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumor in Southeast Asia, its regulatory mechanism is still to be understood. miR-519 inhibits the progression of several tumors, including cervical cancer, ovarian cancer and gastric cancer. But its role in NPC hasn't been studied. In present study, we found miR-519 was downregulated in NPC cells, its overexpression inhibited NPC cell proliferation and arrested cell cycle at G0/G1 phase, while its knockdown promoted NPC cell proliferation and cell cycle progression. An oncogene URG4/URGCP (upregulated gene-4/upregulator of cell proliferation) was the target of miR-519, URG4 was upregulated in NPC cells, miR-519 inhibited URG4 expression by directly binding to the 3'UTR of URG4. miR-519 inhibited Cy din D1 expression and the phosphorylation level of Rb, and increased p21 and p27 expression, confirming miR519 blocked G1 /S transition. Moreover, miR-519 level was negative correlated with URG4 level in NPC tissues. In summary, we found miR-519 NPC cell proliferation by inhibiting URG4. (C) 2017 Elsevier Inc. All rights reserved.
机译：鼻咽癌（NPC）是东南亚最常见的恶性肿瘤之一，其监管机制仍有待理解。 MiR-519抑制了几种肿瘤的进展，包括宫颈癌，卵巢癌和胃癌。但它在NPC中的作用尚未研究。在本研究中，我们发现MiR-519在NPC细胞中下调，其过表达抑制了G0 / G1相的NPC细胞增殖和阻滞细胞周期，而其敲低促进了NPC细胞增殖和细胞周期进展。癌基因URG4 / URGCP（上调基因-4 / uprofulator的细胞增殖）是miR-519的靶标，URG4在NPC细胞中上调，MIR-519通过直接结合URG4的3'UTR抑制URG4表达。 miR-519抑制Cy DIN D1表达和Rb的磷酸化水平，并增加P21和P27表达，确认MiR519阻断G1 / S转变。此外，MIR-519水平与NPC组织中的URG4水平负相关。总之，我们通过抑制URG4发现MiR-519 NPC细胞增殖。 （c）2017年Elsevier Inc.保留所有权利。

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  • 来源
    《Life sciences》 |2017年第2017期|共5页
  • 作者

    Yu Guodong; Zhang Tian; Jing Ying; Bao Qingmin; Tang Qiang; Zhang Yu;

  • 作者单位

    Guizhou Med Univ Affiliated Hosp ENT &

    HN Surg Dept 28 Guiyi St Guiyang 55004 Guizhou Peoples;

    Guizhou Med Univ Affiliated Hosp ENT &

    HN Surg Dept 28 Guiyi St Guiyang 55004 Guizhou Peoples;

    Guizhou Med Univ Affiliated Hosp ENT &

    HN Surg Dept 28 Guiyi St Guiyang 55004 Guizhou Peoples;

    Guizhou Med Univ Affiliated Hosp ENT &

    HN Surg Dept 28 Guiyi St Guiyang 55004 Guizhou Peoples;

    Guizhou Med Univ Affiliated Hosp ENT &

    HN Surg Dept 28 Guiyi St Guiyang 55004 Guizhou Peoples;

    Guizhou Canc Hosp ENT &

    HN Surg Dept Guiyang Guizhou Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医药、卫生;
  • 关键词

    miR-519; URG4; Nasopharyngeal carcinoma; Proliferation;

    机译：miR-519;URG4;鼻咽癌;增殖;

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