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Toll-like receptor 2: An important immunomodulatory molecule during Helicobacter pylori infection

机译：Toll样受体2：幽门螺杆菌感染过程中的重要免疫调节分子

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摘要

Toll like receptors (TLRs) are an essential subset of pathogen recognition receptors (PRRs) which identify the microbial components and contribute in the regulation of innate and adaptive immune responses against the infectious agents. The TLRs, especially TLR2, TLR4, TLR5 and TLR9, participate in the induction of immune response against H. pylori. TLR2 is expressed on a number of immune and non-immune cells and recognizes a vast broad of microbial components due to its potential to form heterodimers with other TLRs, including TLR1, TLR6 and TLR10. A number of H. pylori-related molecules may contribute to TLR2-dependent responses, including HP-LPS, HP-HSP60 and HP-NAP. TLR2 plays a pivotal role in regulation of immune response to H. pylori through activation of NF-kappa B and induction of cytokine expression in epithelial cells, monocytes/macrophages, dendritic cells, neutrophils and B cells. The TLR2-related immune response that is induced by H. pylori-derived components may play an important role regarding the outcome of the infection toward bacterial elimination, persistence or pathological reactions. The immunomodulatory and immunoregulatory roles of TLR2 during H. pylori infection were considered in this review. TLR2 could be considered as an interesting therapeutic target for treatment of H. pylori-related diseases. (C) 2017 Elsevier Inc. All rights reserved.
机译：损伤类似物（TLR）是病原体识别受体（PRRS）的基本子集，其鉴定微生物组分，并有助于调节对传染性剂的先天和适应性免疫应答。 TLRS，尤其是TLR2，TLR4，TLR5和TLR9，参与诱导对幽门螺杆菌的免疫应答。 TLR2在许多免疫和非免疫细胞上表达，并且由于其可能与其他TLR形成异二聚体而识别出大量的微生物组分，包括TLR1，TLR6和TLR10。许多H.幽门螺磁素相关的分子可能有助于TLR2依赖性反应，包括HP-LPS，HP-HSP60和HP-NAP。通过激活NF-Kappa B和上皮细胞，单核细胞/巨噬细胞，树突细胞，中性粒细胞和B细胞的诱导细胞因子表达，在对H. Pylori的调节中发挥枢转作用。 H.幽门螺杆菌衍生的组分诱导的TLR2相关免疫应答可能在对细菌消除，持续性或病理反应的感染结果中起重要作用。在本综述中考虑了TLR2期间TLR2在幽门螺杆菌感染期间的免疫调节和免疫调节作用。 TLR2可被认为是治疗H.幽门螺杆菌相关疾病的有趣治疗靶标。 （c）2017年Elsevier Inc.保留所有权利。

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