Autophagosome formation is required for cardioprotection by chloramphenicol

Giricz Zoltan; Varga Zoltan V.; Koncsos Gabor; Nagya Csilla Terezia; Gorbe Aniko; Mentzer Robert M. Jr.; Gottlieb Roberta A.; Ferdinandy Peter

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Autophagosome formation is required for cardioprotection by chloramphenicol

机译：氯霉素心脏保护需要自噬形成

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Aims: Chloramphenicol (CAP), a broad spectrum antibiotic, was shown to protect the heart against ischemia/ reperfusion (I/R) injury. CAP also induces autophagy, however, it is not known whether CAP-induced cardio-protection is mediated by autophagy. Therefore, here we aimed to assess whether activation of autophagy is required for the infarct size limiting effect of CAP and to identify which component of CAP-induced autophagy contributes to cardioprotection against I/R injury.

机译：目的：显示氯霉素（帽），广泛的抗生素抗生素，用于保护心脏免受缺血/再灌注（I / R）损伤。帽还诱导自噬，但是，尚不清楚概要的心脏保护是否通过自噬介导。因此，在这里，我们旨在评估梗死的梗死大小是否需要自噬激活，并确定帽诱导的自噬的哪些组分有助于对I / R损伤的心脏保护作用。

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来源
《Life sciences》 |2017年第2017期|共6页
作者
Giricz Zoltan; Varga Zoltan V.; Koncsos Gabor; Nagya Csilla Terezia; Gorbe Aniko; Mentzer Robert M. Jr.; Gottlieb Roberta A.; Ferdinandy Peter;
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作者单位

Semmelweis Univ Cardiovasc &

Metab Res Grp Dept Pharmacol &

Pharmacotherapy Budapest Hungary;

Semmelweis Univ Cardiovasc &

Metab Res Grp Dept Pharmacol &

Pharmacotherapy Budapest Hungary;

Semmelweis Univ Cardiovasc &

Metab Res Grp Dept Pharmacol &

Pharmacotherapy Budapest Hungary;

Semmelweis Univ Cardiovasc &

Metab Res Grp Dept Pharmacol &

Pharmacotherapy Budapest Hungary;

Semmelweis Univ Cardiovasc &

Metab Res Grp Dept Pharmacol &

Pharmacotherapy Budapest Hungary;

Cedars Sinai Med Ctr Heart Inst Los Angeles CA 90048 USA;

Cedars Sinai Med Ctr Heart Inst Los Angeles CA 90048 USA;

Semmelweis Univ Cardiovasc &

Metab Res Grp Dept Pharmacol &

Pharmacotherapy Budapest Hungary;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Autophagy; Cardioprotection; Chloramphenicol;

机译：自噬;心脏保护;氯霉素;

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1. Autophagosome formation is required for cardioprotection by chloramphenicol [J] . Giricz Zoltan, Varga Zoltan V., Koncsos Gabor, Life sciences . 2017,第期

机译：氯霉素心脏保护需要自噬形成
2. LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes [J] . Brigitte Langer, Andrea Peschel, Virginie Hubert, Biology Open . 2016,第10期

机译：LAMP-2是将语法素17掺入自噬体和与溶酶体融合所必需的LAMP-2是将语法素17掺入自噬体中和与溶酶体融合所必需的LAMP-2是将语法素17掺入自噬体中和用于LAMP-2所需的。它们与溶酶体的融合
3. De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy [J] . Autophagy . 2020,第6期

机译：副磷脂酰胆碱合成是自噬在自噬膜形成和维护中所必需的
4. Strategic Information System Planning: Information Systems Required in Vocational School Models [C] . Widia Murni Wijaya International Conference on Educational, Management, Administration and Leadership . 2016

机译：战略信息系统规划：职业学校模型所需的信息系统
5. Analysis of the molecular mechanism of autophagosome formation in the yeast Saccharomyces cerevisiae. [D] . Geng, Jiefei. 2010

机译：酵母酿酒酵母中自噬体形成的分子机理分析。
6. Autophagosome formation is required for cardioprotection by chloramphenicol [O] . Zoltán Giricz, Zoltán V. Varga, Gábor Koncsos, -1

机译：氯霉素对心脏的保护需要自噬体的形成
7. Autophagosome formation is required for cardioprotection by chloramphenicol [O] . Zoltán Giricz, Zoltán V. Varga, Gábor Koncsos, 2017

机译：氯霉素心脏保护需要自噬形成

Autophagosome formation is required for cardioprotection by chloramphenicol

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