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Potential therapeutic and protective effect of curcumin against stroke in the male albino stroke-induced model rats

机译：姜黄素对患者患者患者在雄性白血病中风诱导的模型大鼠中的潜在治疗和保护作用

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摘要

Abstract Aims The present study was carried out to understand the therapeutic effect of curcumin (CUR) against stroke in the experimental animal model. The study investigates the healing effect of CUR on mitochondrial dysfunction and inflammation. Materials and methods Male albino, Wistar strain rats were used for the induction of middle cerebral artery occlusion (MCAO), and reperfusion. Enzyme-linked immunosorbent assay (ELISA) was used for the determination of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) in the brain region. Western blot analysis was used to determine the protein expression levels of Bax, Bcl-2, p53, and Sirt1. Key findings The water level was determined in brain region by using standard method. Experimental results indicated that the use of CUR significantly reduced brain edema and water content. IL-6 and TNF-α were significantly reduced in the brain region following use of CUR. Mitochondrial membrane potential (MMP) also reduced significantly after CUR treatment. Protein expression of p53 and Bax were significantly reduced, whereas Bcl-2 and Sirt1 were increased following CUR treatment. Significance Taking all these data together, it is suggested that the use of CUR may be a potential therapeutic agent for the treatment of stroke. ]]>
机译：摘要目的本研究是为了了解姜黄素（Cur）对实验动物模型中风的治疗效果。该研究调查了Cur对线粒体功能障碍和炎症的愈合效应。材料和方法雄性白化物，Wistar菌株大鼠用于诱导中脑动脉闭塞（MCAO）和再灌注。酶联免疫吸附试验（ELISA）用于测定脑区中白细胞介素6（IL-6）和肿瘤坏死因子α（TNF-α）。 Western印迹分析用于确定Bax，Bcl-2，p53和Sirt1的蛋白质表达水平。主要发现通过使用标准方法在脑区域中测定水位。实验结果表明，使用Cur显着降低了脑水肿和水含量。在使用CUR后，脑区域显着降低IL-6和TNF-α。在处理后，线粒体膜电位（MMP）也显着降低。 P53和Bax的蛋白质表达显着降低，而Bcl-2和Sirt1在Cur处理后增加。将所有这些数据的意义在一起，建议使用Cur可以是用于治疗中风的潜在治疗剂。 ]]>

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  • 来源
    《Life sciences》 |2017年第2017期|共5页
  • 作者

    Yuanyuan Zhang; Yi Yan; Yi Cao; Yongtao Yang; Qing Zhao; Rui Jing; Jiayi Hu; Juan Bao;

  • 作者单位

    Department of Cerebrovascular Disease The Second Affiliated Hospital Kunming Medical University;

    Department of Anesthesiology Kunming General Hospital of Chengdu Military Command;

    Department of Cerebrovascular Disease The Second Affiliated Hospital Kunming Medical University;

    Department of Cerebrovascular Disease The Second Affiliated Hospital Kunming Medical University;

    Department of Cerebrovascular Disease The Second Affiliated Hospital Kunming Medical University;

    Department of Cerebrovascular Disease The Second Affiliated Hospital Kunming Medical University;

    Department of Cerebrovascular Disease The Second Affiliated Hospital Kunming Medical University;

    Department of Cerebrovascular Disease The Second Affiliated Hospital Kunming Medical University;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医药、卫生;
  • 关键词

    Curcumin; Stroke; p53; Bax; TNF-α;

    机译：姜黄素;中风;p53;bax;tnf-α;

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