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Does resistance exercise performed during dialysis modulate Nrf2 and NF-κB in patients with chronic kidney disease?

机译：在透析在慢性肾病患者中调节NRF2和NF-κB时进行的抗性运动是否调节NRF2和NF-κB？

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Abstract Studies have shown that nuclear factor erythroid 2-related factor 2 (Nrf2) can be modulated by physical exercise. However, the impact of resistance exercise has never been investigated in patients with chronic kidney disease (CKD). The aim of this study was to evaluate the effects of resistance exercise programs on the expression of transcription factors Nrf2 and nuclear factor κB (NF-κB) in CKD patients on hemodialysis (HD). Patients on an HD program were randomly assigned to an exercise group of 25 patients (54.5% women, aged 45.7 ± 15.2 years and time on dialysis = 71.2 ± 45.5 months) or a control group of 19 patients who had no exercise intervention (61.5% women, aged 42.5 ± 13.5 years and time on dialysis = 70.1 ± 49.9 months). A strength exercise program was performed 3 times a week during the HD sessions. Peripheral blood mononuclear cells were isolated and processed for the expression of Nrf2 and NF-κB by quantitative real-time polymerase chain reaction 3 months before and after the exercise program. Using an enzyme-linked immunosorbent assay, the activity of glutathione peroxidase (GPx) as well as the products of high-sensitivity C-reactive protein and nitric oxide (NO) were assessed. Nrf2 expression (ranging from 0.86 ± 0.4 to 1.76 ± 0.8) and GPx activity were significantly increased after exercise intervention. In the exercise group, no difference in the levels of NO was observed; however, there was a significant reduction in the control group. In conclusion, these data suggest that resistance exercises seem to be capable of inducing Nrf2 activation in CKD patients on HD.
机译：有抽象的研究表明，核因子红系2相关因子2（Nrf2的）可以通过体育锻炼来调节。然而，抵抗运动的影响从未在慢性肾脏病（CKD）的影响。 CKD患者本研究的目的是评估的转录表达性的运动项目的影响因素NRF2的核因子κB（NF-κB）在血液透析（HD）。在高清节目患者被随机分配到锻炼组25例（54.5％为女性，透析= 71.2±45.5个月年龄45.7±15.2年和时间）或19例谁没有运动干预对照组（61.5％妇女在透析年龄42.5±13.5年和时间= 70.1±49.9个月）。强度的锻炼计划是在HD会议每周进行3次。外周血单核细胞的分离和对Nrf2和NF-κB的通过定量实时聚合酶链式反应前3个月和锻炼程序之后表达处理。使用酶联免疫吸附测定，谷胱甘肽过氧化物酶的酶（GPx）的活性以及高灵敏度C-反应蛋白和一氧化氮（NO）的产品进行了评估。 Nrf2的表达（范围从0.86±0.4 1.76±0.8）和GPx活性运动干预后显著增加。在运动组中，NO的水平没有差异观察到;然而，在对照组中一个显著减少。总之，这些数据表明，抵抗运动似乎能够在CKD患者HD诱导Nrf2的激活。

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