• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Surface design and preparation of multi-functional magnetic nanoparticles for cancer cell targeting, therapy, and imaging
【24h】

Surface design and preparation of multi-functional magnetic nanoparticles for cancer cell targeting, therapy, and imaging

机译：用于癌细胞靶向，治疗和成像的多功能磁性纳米粒子的表面设计和制备

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recently, theranostic candidates based on superparamagnetic iron oxide nanoparticles (SPIONs) providing the combination of therapy and diagnosis have become one of the most promising system in cancer research. However, poor stability, premature drug release, lack of specific tumor cell targeting, and complicated multi-step synthesis processes still hinder them for potential clinical applications. In this research, the multi-functional magnetic nanoparticles (MNPs-DOX) were prepared via a simple assembly process for targeted delivery of doxorubicin (DOX) and enhanced magnetic resonance (MR) imaging detection. Firstly, the multi-functional copolymer coating, polyamidoamine (PAMAM), was designed and synthesized by Michael addition reaction, where N,N-bis(acryloyl)cystamine served as backbone linker, and DOX, dopamine (DA), and polyethylene glycol (PEG) acted as comonomers. The PAMAM was then directly assembled to the surface of SPIONs by the ligand exchange reaction with SPIONs forming the MNPs-DOX. The hydrophilic PEG moieties provide the nanoparticles with colloidal stability and good-dispersity in aqueous solution. Comparing with the quick release of free DOX, the drug release behavior of MNPs-DOX exhibited a sustained drug release. Because the chemical cleavage of disulfide in the polymer backbone, a high cumulative drug release up to 60% in GSH within 48 h was observed, rather than only 26% in PBS (pH 7.4) without GSH. The MR imaging detection experiment showed that the MNPs-DOX had an enhanced T-2 relaxivity of 126 mM(-1) S-1 for MR imaging. The results of the cytotoxicity assays showed a remarkable killing effect of cancer cells by MNPs-DOX due to the FA tumor-targeting ligand, comparing with non-targeted drug molecules. All the results showed that the as prepared multi-functional magnetic nanoparticles may serve as a promising theranostic candidate for targeted anticancer drug delivery and efficient detection through MR imaging in medical application.
机译：最近，基于超顺磁性氧化铁纳米粒子（栓塞）的治疗师提供了治疗和诊断组合的候选者已成为癌症研究中最有前途的系统之一。然而，稳定性差，过早药物释放，缺乏特异性肿瘤细胞靶向，并且复杂的多步合成过程仍然阻碍它们潜在的临床应用。在该研究中，通过简单的组装方法制备多功能磁性纳米颗粒（MNPS-DOX），用于靶向递送多柔比星（DOX）和增强的磁共振（MR）成像检测。首先，通过迈克尔加成反应设计和合成多功能共聚物涂层，聚酰胺胺（PAMAM），其中N，N-BIS（丙烯酰基）胱胺作为骨架接头，DOX，多巴胺（DA）和聚乙二醇（ PEG）担任共聚单体。然后通过与形成MNPS-DOX的酱的配体交换反应将PAMAM直接组装到胶片表面上。亲水性PEG部分提供纳米颗粒，具有胶体稳定性和水溶液中的良好分散性。与免费释放免费DOX的比较，MNPS-DOX的药物释放行为表现出持续的药物释放。因为在聚合物主链中二硫化物的化学切割，观察到48小时内高达60％的高累积药物释放，而不是在没有GSH的情况下仅26％的PBS（pH7.4）。 MR成像检测实验表明的MNP-DOX具有126毫米（-1）的增强的T-2弛豫S-1用于MR成像。由于FA肿瘤靶向配体，细胞毒性测定的结果显示了MNPS-DOX的显着杀伤效果，与非靶向药物分子相比。所有结果表明，所制备的多功能磁性纳米颗粒可以用作用于在医疗应用靶向抗癌药物输送和有效地检测通过MR成像有希望的治疗诊断的候选。

著录项

  • 来源
    《RSC Advances》 |2018年第62期|共11页
  • 作者

    Qu Jing; Tian Zhijie; Wang Qiuyue; Peng Si; Luo Jian-bin; Zhou Qing-han; Lin Juan;

  • 作者单位

    Southwest Minzu Univ Coll Chem &

    Environm Protect First Ring Rd 4th Sect 16 Chengdu 610041 Sichuan Peoples R China;

    Chengdu Med Coll Sch Biomed Sci &

    Technol 783 Xindu Rd Chengdu 610500 Sichuan Peoples R China;

    Southwest Minzu Univ Coll Chem &

    Environm Protect First Ring Rd 4th Sect 16 Chengdu 610041 Sichuan Peoples R China;

    Southwest Minzu Univ Coll Chem &

    Environm Protect First Ring Rd 4th Sect 16 Chengdu 610041 Sichuan Peoples R China;

    Southwest Minzu Univ Coll Chem &

    Environm Protect First Ring Rd 4th Sect 16 Chengdu 610041 Sichuan Peoples R China;

    Southwest Minzu Univ Coll Chem &

    Environm Protect First Ring Rd 4th Sect 16 Chengdu 610041 Sichuan Peoples R China;

    Chengdu Med Coll Sch Biomed Sci &

    Technol 783 Xindu Rd Chengdu 610500 Sichuan Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号