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首页> 外文期刊>RSC Advances >Chitosan-based self-assembled nanocarriers coordinated to cisplatin for cancer treatment
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Chitosan-based self-assembled nanocarriers coordinated to cisplatin for cancer treatment

机译：基于壳聚糖的自组装纳米载体与顺铂相辅相成的癌症治疗

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摘要

Polymeric nanocarriers were prepared via a dialysis method using three chitosan derivatives, N-benzyl-N,O-succinyl chitosan (BSCT), N-naphthyl-N,O-succinyl chitosan (NSCT), and N-octyl-N-O-succinyl chitosan (OSCT) and were coordinated to cisplatin. The nanocarrier properties and cytotoxicity on the human carcinoma cells, HN22 (head and neck), were investigated. In addition, intracellular cisplatin accumulation, apoptosis induction and toxicity on renal cells were also evaluated. The findings revealed that the succinyl groups of the polymers were perfectly deprotonated and bound with cisplatin by co-ordinate bonds at pH 8.5. Among the derivatives, BSCT exhibited the highest cisplatin loading and release in simulated physiological medium. The cytotoxicities on HN22 cells of cisplatin-loaded BSCT nanocarriers were lower than that of free cisplatin, however, they presented a greater percentage of early apoptosis in HN22 cells and could decrease cisplatin induced renal cell death. In conclusion, the BSCT self-assembly nanocarrier might be a cisplatin carrier for sustained release, which provides prolonged antitumour treatment and reduced nephrotoxicity.
机译：通过使用三种壳聚糖衍生物，N-苄基-N，O-琥珀酰壳聚糖（BSCT），N-Naphthyl-N，O-琥珀酰壳聚糖（NSCT）和N-辛基 - 非琥珀酰壳聚糖，通过透析方法制备聚合物纳米载体。 （OSCT）并与顺铂协调。研究了人癌细胞，HN22（头部和颈部）上的纳米载体性质和细胞毒性。此外，还评估了肾细胞细胞内的顺铂积累，凋亡诱导和毒性。结果表明，聚合物的琥珀酰基通过在pH8.5的统序键上完全脱质并与顺铂与顺铂结合。在衍生物中，BSCT在模拟生理培养基中表现出最高的顺铂载荷和释放。顺铂加载的BSCT纳米载体HN22细胞的细胞毒性低于免费的顺铂的细胞毒素，但它们在HN22细胞中提高了更高百分比的早期凋亡，可以降低顺铂诱导的肾细胞死亡。总之，BSCT自组装纳米载体可能是持续释放的顺铂载体，其提供延长的抗肿瘤治疗和降低的肾毒性。

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  • 来源
    《RSC Advances》 |2018年第41期|共7页
  • 作者

    Trummer Ronny; Rangsimawong Worranan; Sajomsang Warayuth; Kumpugdee-Vollrath Mont; Opanasopit Praneet; Tonglairoum Prasopchai;

  • 作者单位

    Univ Appl Sci Beuth Hsch Tech Berlin Fac Pharmaceut &

    Chem Engn D-13353 Berlin Germany;

    Silpakorn Univ Fac Pharm PDGIG Nakhon Pathom 73000 Thailand;

    Natl Sci &

    Technol Dev Agcy Natl Nanotechnol Ctr NANOTEC Thailand Sci Pk Pathum Thani 12120 Thailand;

    Univ Appl Sci Beuth Hsch Tech Berlin Fac Pharmaceut &

    Chem Engn D-13353 Berlin Germany;

    Silpakorn Univ Fac Pharm PDGIG Nakhon Pathom 73000 Thailand;

    Silpakorn Univ Fac Pharm PDGIG Nakhon Pathom 73000 Thailand;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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