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首页> 外文期刊>RSC Advances >Acid-promoted iron-catalysed dehydrogenative [4+2] cycloaddition for the synthesis of quinolines under air
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Acid-promoted iron-catalysed dehydrogenative [4+2] cycloaddition for the synthesis of quinolines under air

机译：酸促进的铁催化脱氢[4 + 2]环加成用于在空气下合成喹啉

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摘要

An acid-promoted iron-catalysed dehydrogenative [4 + 2] cycloaddition reaction was developed for the synthesis of quinolines using air as a terminal oxidant. Acetic acid was the best cocatalyst for the cycloaddition of N-alkyl anilines with alkenes or alkynes under air. Various quinoline derivatives were obtained in satisfactory-to-excellent yields, and no other byproducts besides water were produced in the reaction. The zebrafish model has become an important vertebrate model for evaluating drug effects. We tested the activity of 3n in zebrafish. The test results showed that 1 g mL(-1)3n treatments resulted in morphological malformation, and 0.01-0.1 g mL(-1)3n treatments led to potent angiogenic defects in zebrafish embryos. The results of this study will be of great significance for promoting drug research in cardiovascular and cerebrovascular diseases.
机译：酸促进的铁催化的脱氢[4 + 2]环加入反应用于合成使用空气作为末端氧化剂的喹啉。 醋酸是N-烷基苯胺环加成的最佳助催化剂，其在空气下与烯烃或炔烃。 以令人满意的至优异的产率获得各种喹啉衍生物，并在反应中产生除水之外的其他副产物。 斑马鱼模型已成为评估药物影响的重要脊椎动物模型。 我们在斑马鱼中测试了3N的活动。 测试结果表明，1g ml（-1）3N处理导致形态畸形，0.01-0.1g ml（-1）3n治疗导致斑马鱼胚胎中有效的血管生成缺陷。 该研究的结果将对促进心血管和脑血管疾病的药物研究具有重要意义。

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  • 来源
    《RSC Advances》 |2018年第55期|共5页
  • 作者

    Yang Jinfei; Meng Xiao; Lu Kai; Lu Zhihao; Huang Minliang; Wang Chengniu; Sun Fei;

  • 作者单位

    Nantong Univ Inst Reprod Med Med Sch Nantong 226019 Peoples R China;

    Nantong Univ Inst Reprod Med Med Sch Nantong 226019 Peoples R China;

    Nantong Univ Inst Reprod Med Med Sch Nantong 226019 Peoples R China;

    Nantong Univ Inst Reprod Med Med Sch Nantong 226019 Peoples R China;

    Nantong Univ Inst Reprod Med Med Sch Nantong 226019 Peoples R China;

    Nantong Univ Inst Reprod Med Med Sch Nantong 226019 Peoples R China;

    Nantong Univ Inst Reprod Med Med Sch Nantong 226019 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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