• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Knockdown of UCA1 inhibits viability and glycolysis by suppressing PKM2 expression through the mTOR pathway in non-small cell lung cancer cells
【24h】

Knockdown of UCA1 inhibits viability and glycolysis by suppressing PKM2 expression through the mTOR pathway in non-small cell lung cancer cells

机译：UCA1的敲低通过抑制非小细胞肺癌细胞中的MTOR途径来抑制PKM2表达来抑制活力和糖酵解

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

LncRNA urothelial carcinoma associated 1 (UCA1) was reported to be upregulated in non-small cell lung cancer (NSCLC) tissues and contributed to NSCLC progression. Additionally, it has been proposed that the oncogenic role of UCA1 may be related to glucose metabolism in bladder cancer. However, whether and how UCA1 regulates glucose metabolism in the progression of NSCLC remains unknown. Our results showed that knockdown of UCA1 inhibited the viability of NSCLC cells. UCA1 silencing suppressed glycolysis of NSCLC cells by reducing the glucose consumption and lactate production. Additionally, knockdown of UCA1 suppressed PKM2 expression and the mTOR pathway in NSCLC cells. Mechanistically, PKM2 knockdown suppressed the effects of UCA1 on viability and glycolysis of NSCLC cells and inhibition of the mTOR pathway suppressed the effects of UCA1 on viability, glycolysis, and PKM2 expression in NSCLC cells. In conclusion, knockdown of UCA1 inhibited viability and glycolysis by suppressing PKM2 expression maybe through the mTOR pathway in NSCLC cells, providing a novel insight into the molecular mechanism of UCA1 involved in the regulation of glucose metabolism in NSCLC cells.
机译：据报道，LNCRNA尿路上皮癌相关1（UCA1）在非小细胞肺癌（NSCLC）组织中升高，并导致NSCLC进展。另外，已经提出了UCA1的致癌作用可能与膀胱癌中的葡萄糖代谢有关。然而，UCA1如何调节NSCLC进展中的葡萄糖代谢仍然未知。我们的研究结果表明，UCA1的敲低抑制了NSCLC细胞的活力。 UCA1通过降低葡萄糖消耗和乳酸产生来沉默抑制NSCLC细胞的糖酵解。另外，UCA1的敲低抑制了NSCLC细胞中的PKM2表达和MTOR途径。机械地，PKM2敲低抑制了UCA1对NSCLC细胞的活力和糖醇分解的影响，并且MTOR途径的抑制抑制了UCA1对NSCLC细胞中活力，糖酵解和PKM2表达的影响。总之，通过抑制PKM2表达可以通过NSCLC细胞中的MTOR途径来抑制UCA1抑制活力和糖酵解，提供了对参与NSCLC细胞中葡萄糖代谢的UCA1的分子机制的新颖洞察力。

著录项

  • 来源
    《RSC Advances》 |2018年第19期|共10页
  • 作者

    Wang Xuguang; Fa Xian-En;

  • 作者单位

    Zhengzhou Univ Affiliated Hosp 1 Dept Thorac Surg Zhengzhou 450052 Peoples R China;

    Zhengzhou Univ Affiliated Hosp 2 Dept Cardiothorac Surg 2 Jingba Rd Zhengzhou 450014 Henan Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号