A novel fluorescent probe for imaging the process of HOCl oxidation and Cys/Hcy reduction in living cells

Liu Zhen; Li Guoping; Wang Yana; Li Jiulong; Mi Yang; Guo Linna; Xu Wenjian; Zou Dapeng; Li Tiesheng; Wu Yangjie

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A novel fluorescent probe for imaging the process of HOCl oxidation and Cys/Hcy reduction in living cells

机译：一种用于成像的新型荧光探针，用于对活细胞的Hocl氧化和Cys / Hcy降低的过程

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摘要

A new on-off-on fluorescent probe, CMOS, based on coumarin was developed to detect the process of hypochlorous acid (HOCl) oxidative stress and cysteine/homocysteine (Cys/Hcy) reduction. The probe exhibited a fast response, good sensitivity and selectivity. Moreover, it was applied for monitoring the redox process in living cells.

机译：开发了一种基于香豆素的新的开启荧光探针，CMOS，以检测次氯酸（HOCL）氧化应激和半胱氨酸/同型胰岛素（CYS / HCY）还原过程的过程。探针表现出快速响应，良好的敏感性和选择性。此外，它用于监测活细胞中的氧化还原过程。

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来源
《RSC Advances》 |2018年第17期|共5页
作者
Liu Zhen; Li Guoping; Wang Yana; Li Jiulong; Mi Yang; Guo Linna; Xu Wenjian; Zou Dapeng; Li Tiesheng; Wu Yangjie;
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作者单位

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

Zhengzhou Univ Sch Basic Med Sci Zhengzhou 450001 Henan Peoples R China;

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

Zhengzhou Univ Coll Chem &

Mol Engn Zhengzhou 450001 Henan Peoples R China;

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正文语种 eng
中图分类化学;
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专利

1. A novel fluorescent probe for imaging the process of HOCl oxidation and Cys/Hcy reduction in living cells [J] . Liu Zhen, Li Guoping, Wang Yana, RSC Advances . 2018,第17期

机译：一种用于成像的新型荧光探针，用于对活细胞的Hocl氧化和Cys / Hcy降低的过程
2. Quinoline-derived fluorescent probes for the discrimination of Cys from Hcys/GSH and bioimaging in living cells [J] . Wu Qingqing, Mao Mao, Liang Wenlang, Talanta: The International Journal of Pure and Applied Analytical Chemistry . 2018,第期

机译：喹啉衍生的荧光探针，用于识别HCYS / GSH和活细胞中的生物成像的CYS
3. A ratiometric and near-infrared fluorescent probe for discrimination of Cys/Hcy/GSH in aqueous solution and its intracellular imaging in living cells [J] . Bai Jin, Yang Xin, Qian Ying Autonomic neuroscience: basic & clinical . 2019,第1期

机译：用于识别水溶液中Cys / Hcy / GSH的比例和近红外荧光探针及其在活细胞中的细胞内成像
4. Novel Tag-probe Pairs for Fluorescent Imaging of Proteins in Living Cells [C] . Wataru Nomura, Nami Ohashi, Atsumi Mori Japanese peptide symposium . 2011

机译：新型标签探针对活细胞蛋白质荧光成像对
5. cHOClate: A DNA-Based Fluorescent Probe to Quantitatively Map Subcellular HOCl [D] . Thekkan, Shareefa 2019

机译：cHOColate：基于DNA的荧光探针，可定量定位亚细胞HOCl
6. A minimalist fluorescent probe for differentiating Cys Hcy and GSH in live cells [O] . Huatang Zhang, Ruochuan Liu, Jie Liu, 2016

机译：用于区分活细胞中CysHcy和GSH的极简荧光探针
7. Development of a New Carbon Monoxide Fluorescent Probe Based on Nitro Reduction and Its Bioimaging Research in Living Cells [O] . Enqing Chen, Yonghe Tang, Lei Wang, 2021

机译：基于硝基降低的新型一氧化碳荧光探针及其生物细胞生物体研究的研制

A novel fluorescent probe for imaging the process of HOCl oxidation and Cys/Hcy reduction in living cells

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