• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Vancomycin-loaded titanium coatings with an interconnected micro-patterned structure for prophylaxis of infections: an in vivo study
【24h】

Vancomycin-loaded titanium coatings with an interconnected micro-patterned structure for prophylaxis of infections: an in vivo study

机译：加载Vancomycin的钛涂层，具有互连的微图案结构，用于预防感染：体内研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Titanium (Ti) and its alloys are widely applied as orthopedic implants for hip and knee prostheses, fixation, and dental implants. However, Ti and its alloys are bioinert and susceptible to bacteria and biofilm formation. Thus, surface biofunctionalisation of Ti is essential for improving the biofunction of Ti. The current in vitro study indicated that calcium phosphate bone cement with vancomycin doped on micro-patterned Ti with a grid-like structure surface could preserve the property of inhibition of bacterial adhesion and biofilm formation while not affecting the osteogenic differentiation. The present study investigated whether the biological performance of the bactericidal effect is preserved in vivo. The rabbit osteomyelitis model with tibial medullary cavity placement of Ti rods was employed to analyze the antibacterial effect of vancomycin-loaded Ti coatings with interconnected micro-patterned structure (TV). Thirty female rabbits (N = 10) were used to establish the implant-associated infection. Prior to implanting the TO and TV rods into the medullary cavity of the Left tibia of the rabbits, 10(6) CFU mL(-1) methicillin-resistant Staphylococcus aureus (MRSA) was injected into the medullary cavity of the Left tibia of the rabbits. The sterile Ti rod (NT) was used as the blank control. After 3 weeks, bone pathology was evaluated using X-ray and micro-CT. The in vivo study proposed that TV has the potential for prophylaxis against MRSA infection. Thus, the interconnected micro-patterned structured Ti rods Loaded with vancomycin could be applied for preventing Ti implant-associated infections.
机译：钛（Ti）及其合金被广泛应用于髋关节和膝关节假体，固定和牙科植入物的整形外科植入物。然而，Ti及其合金是生物素线，易受细菌和生物膜形成的影响。因此，Ti的表面生物功能对于改善Ti的生物功能至关重要。目前的体外研究表明，磷酸钙骨水泥用掺杂在微图案化的Ti上具有网格状结构表面的磷酸钙骨水泥可以保持抑制细菌粘附和生物膜形成的性质，同时不影响骨质发生分化。本研究研究了杀菌效果的生物学性能是否保存在体内。使用Ti杆胫骨髓腔腔放置的兔骨髓炎模型分析了互联的微图案结构（TV）的万古霉素装载的Ti涂层的抗菌作用。使用三十个雌性兔（n = 10）来建立植入物相关的感染。之前注入TO和电视棒入家兔的左胫骨的骨髓腔，10（6）CFU毫升（-1）耐甲氧西林金黄色葡萄球菌（MRSA）注入的左胫骨的骨髓腔兔子。无菌Ti棒（NT）用作空白控制。 3周后，使用X射线和微型CT评估骨病理学。在体内研究提出，TV具有对MRSA感染的预防潜力。因此，可以施加装有万古霉素的互连的微图案化结构Ti棒用于预防Ti植入物相关的感染。

著录项

  • 来源
    《RSC Advances》 |2018年第17期|共9页
  • 作者

    Zhang Hao; Wang Guangchao; Liu Peizhao; Tong Dake; Ding Chen; Zhang Zequan; Xie Youtao; Tang Hao; Ji Fang;

  • 作者单位

    Second Mil Med Univ Changhai Hosp Dept Orthoped 168 Changhai Rd Shanghai 200433 Peoples R China;

    Second Mil Med Univ Changhai Hosp Dept Orthoped 168 Changhai Rd Shanghai 200433 Peoples R China;

    Second Mil Med Univ Changhai Hosp Dept Orthoped 168 Changhai Rd Shanghai 200433 Peoples R China;

    Second Mil Med Univ Changhai Hosp Dept Orthoped 168 Changhai Rd Shanghai 200433 Peoples R China;

    Second Mil Med Univ Changhai Hosp Dept Orthoped 168 Changhai Rd Shanghai 200433 Peoples R China;

    Chinese Acad Sci Shanghai Inst Ceram Key Lab Inorgan Coating Mat Shanghai Peoples R China;

    Chinese Acad Sci Shanghai Inst Ceram Key Lab Inorgan Coating Mat Shanghai Peoples R China;

    Second Mil Med Univ Changhai Hosp Dept Orthoped 168 Changhai Rd Shanghai 200433 Peoples R China;

    Second Mil Med Univ Changhai Hosp Dept Orthoped 168 Changhai Rd Shanghai 200433 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号