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首页> 外文期刊>RSC Advances >Down-regulation of Rab10 inhibits hypoxia-induced invasion and EMT in thyroid cancer cells by targeting HIF-1 through the PI3K/Akt pathway
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Down-regulation of Rab10 inhibits hypoxia-induced invasion and EMT in thyroid cancer cells by targeting HIF-1 through the PI3K/Akt pathway

机译：通过通过PI3K / AKT途径靶向HIF-1，rab10的下调抑制缺氧诱导的甲状腺癌细胞中的侵袭和EMT

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摘要

Rab10, a member of the Rab family, is localized to endocytic compartments and serves as a regulator of intracellular vesicle trafficking. Previous studies mainly paid attention to the role of Rab10 in transport. Recently, Rab10 has been reported to be involved in the progression of various cancers. However, the biological functions of Rab10 in thyroid cancer remain unknown. In this study, we demonstrated that Rab10 was highly expressed in thyroid cancer tissues and cell lines. Down-regulation of Rab10 inhibited hypoxia-induced migration, invasion and epithelial-mesenchymal transition (EMT) of thyroid cancer cells. Moreover, HIF-1 and the PI3K/Akt pathway were involved in the inhibitory effect of Rab10 down-regulation on thyroid cancer cell invasion and EMT induced by hypoxia. Taken together, our study provided further evidence to support the role of Rab10 as a therapeutic target for thyroid cancer.
机译：Rab10是Rab家族的成员，本地化为内吞室，用作细胞内囊泡贩运的调节剂。 以前的研究主要关注RAB10在运输中的作用。 最近，据报道，RAB10涉及各种癌症的进展。 然而，Rab10在甲状腺癌中的生物学功能仍然未知。 在这项研究中，我们证明RAB10在甲状腺癌组织和细胞系中高度表达。 Rab10的下调抑制缺氧诱导的迁移，侵袭和上皮 - 间充质转换（EMT）的甲状腺癌细胞。 此外，HIF-1和PI3K / AKT途径涉及RAB10下调对缺氧诱导的甲状腺癌细胞侵袭和EMT的抑制作用。 我们的研究携带，我们的研究提供了进一步的证据来支持RAB10作为甲状腺癌的治疗靶标的作用。

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  • 来源
    《RSC Advances》 |2018年第55期|共8页
  • 作者

    Zhou Zhenyu; Liu Yang; Hu Zhuang; Ma Mingde; Chang Liang;

  • 作者单位

    Henan Univ Huaihe Hosp Dept Thyroid &

    Breast 8 Baobei Rd Kaifeng 475000 Peoples R China;

    Henan Univ Huaihe Hosp Dept Endocrinol Kaifeng 475000 Peoples R China;

    Henan Univ Huaihe Hosp Dept Thyroid &

    Breast 8 Baobei Rd Kaifeng 475000 Peoples R China;

    Henan Univ Huaihe Hosp Dept Thyroid &

    Breast 8 Baobei Rd Kaifeng 475000 Peoples R China;

    Henan Univ Huaihe Hosp Dept Thyroid &

    Breast 8 Baobei Rd Kaifeng 475000 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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