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首页> 外文期刊>RSC Advances >Hansforesters A-M, polyesters from the sponge-associated fungus Hansfordia sinuosae with antibacterial activities
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Hansforesters A-M, polyesters from the sponge-associated fungus Hansfordia sinuosae with antibacterial activities

机译：Hansoresters A-M，来自海绵相关的真菌的聚酯，汉森西氏菌具有抗菌活动

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摘要

Bioassay-guided fractionation and chromatographic separation of a sponge-derived fungus Hansfordia sinuosae, resulted in the isolation of thirteen new polyesters namely hansforesters A-M (1-13), along with five known analogues involving ascotrichalactone A, ascotrichester B, 15G256, 6R-hydroxymellein, and (-)orthosporin. The structures of the new compounds were determined through extensive spectroscopic analysis, in addition to the chemical conversion for the configurational assignment. The polyesters incorporating the motifs of orsellinic acid, 2,4-dihydroxy-6-acetonylbenzoic acid, and orcinotriol were found from nature for the first time. Hansforester A (1) and ascotrichalactone A exhibited potent inhibition against a panel of bacterial strains, including the agricultural pathogenic bacteria, Pseudomonas lachrymans, Agrobacterium tumefaciens, Xanthomonas vesicatoria, and Ralstonia solanacearum, with the MIC values of 15.6 M, and the human infected bacterium Staphylococcus aureus with the MIC values of 3.9 M. These findings suggested that hansforester A and ascotrichalactone A are the potential leads to be developed as the antibacterial agents for the treatment of agriculture bacterial pathogens.
机译：生物测定引导的分馏和分离海绵衍生的真菌汉森窦鼻窦，导致13个新的聚酯分离，即Hanseresters Am（1-13），以及涉及ascoTrichalactere a，ascottrichester b，15g256，6r-羟基蛋白的五种已知的类似物（ - ）矫孢菌素。除了配置分配的化学转化之外，通过广泛的光谱分析确定新化合物的结构。首次发现包含甲硅烷酸，2,4-二羟基-6-乙酰苯甲酸和赤烟醇的基序的聚酯。 Hansforester A（1）和ascoTriChalactone A对细菌菌株的效果有效抑制，包括农业致病菌，Pseudomonas Lachrymans，Tumefaciens，Xanthomonas肠道和洛尔逊尼菌和洛伦西亚氏菌蛋白，MIC值为15.6米和人类感染细菌金黄色葡萄球菌具有3.9米的MIC值。这些研究结果表明，汉森林A和ascoTriChalactone A是潜在的导致作为治疗农业细菌病原体的抗菌剂。

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  • 来源
    《RSC Advances》 |2018年第69期|共13页
  • 作者

    Wu Zehong; Liu Dong; Huang Jian; Proksch Peter; Zhu Kui; Lin Wenhan;

  • 作者单位

    Peking Univ State Key Lab Nat &

    Biomimet Drugs Beijing 100191 Peoples R China;

    Peking Univ State Key Lab Nat &

    Biomimet Drugs Beijing 100191 Peoples R China;

    Peking Univ State Key Lab Nat &

    Biomimet Drugs Beijing 100191 Peoples R China;

    Heinrich Heine Univ Dusseldorf Inst Pharmazeut Biol &

    Biotechnol D-40225 Dusseldorf Germany;

    China Agr Univ Coll Vet Med Beijing 100193 Peoples R China;

    Peking Univ State Key Lab Nat &

    Biomimet Drugs Beijing 100191 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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