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首页> 外文期刊>RSC Advances >Preventive effect of goby fish protein hydrolysates on hyperlipidemia and cardiovascular disease in Wistar rats fed a high-fat/fructose diet
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Preventive effect of goby fish protein hydrolysates on hyperlipidemia and cardiovascular disease in Wistar rats fed a high-fat/fructose diet

机译：Goby Fish蛋白水解对Hymitipidemia和心血管疾病的预防效果喂养高脂/果糖饮食

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摘要

This study was carried out to investigate the hypolipidemic, cardioprotective and anticoagulant properties of fish goby protein hydrolysates (GPHs) in rats fed a high fat and fructose diet (HFFD). Wistar rats were fed with HFFD for 2 months, coupled with the oral administration of GPHs and undigested goby protein (UGP). Compared with the standard diet, HFFD induced dyslipidemia and liver structure alterations, and increased pancreatic lipase activity. In addition, HFFD caused a significant increase in body weight. Interestingly, administration of UGP and GPHs to HFFD fed rats was efficacious in lowering serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-c) as well as hepatic TC and TG, and increased the serum high density lipoprotein cholesterol (HDL-c) content. Moreover, all treatments significantly decreased the atherogenic index and coagulant factor levels (thrombin and prothrombin). UGP and GPH administration also significantly decreased pancreatic lipase activity, which mitigates lipid accumulation. Similarly, UGP and its hydrolysates showed cardioprotective potential revealed by decreasing the risk of atherogenic and coronary artery disease and improving the liver architecture. The ex vivo plasma clotting test showed that GPHs exert a great therapeutic anticoagulant potential. The overall results demonstrated that GPH supplementation can counteract high-fat/fructose diet-induced obesity.
机译：这项研究进行了在喂食高脂肪和果糖饮食（HFFD）老鼠来研究鱼类虾虎鱼蛋白水解物（GPHS）的降血脂，保护心脏和抗凝血特性。 Wistar大鼠用HFFD喂养2个月，加上GPHS和未消化的虾虎鱼蛋白（UGP）的口服给药。与标准饮食相比，HFFD引起血脂异常和肝脏结构的改变，并增加了胰脂肪酶活性。此外，HFFD造成体重显著增加。有趣的是，UGP和GPHS到HFFD施用喂养的大鼠在降低血清总胆固醇（TC），甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）以及肝TC和TG有效的，并增加了血清高密度脂蛋白胆固醇（HDL-C）的含量。此外，所有的治疗显著降低动脉硬化指数和凝结剂因子水平（凝血酶和凝血酶原）。 UGP和GPH政府也显著降低胰脂肪酶的活性，从而减轻脂肪堆积。同样，UGP及其水解物显示出通过降低动脉粥样硬化和冠心病的风险，提高肝脏的结构揭示了心脏的潜力。体外血浆凝固试验表明，GPHS发挥巨大的治疗潜能抗凝剂。总体结果表明，GPH补充剂可以抵消高脂肪/果糖饮食诱导的肥胖。

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  • 来源
    《RSC Advances》 |2018年第17期|共11页
  • 作者

    Nasri Rim; Abdelhedi Ola; Jemil Ines; Ben Amor Ikram; Elfeki Abdelfattah; Gargouri Jalel; Boualga Ahmed; Karra-Chaabouni Maha; Nasri Moncef;

  • 作者单位

    Univ Sfax Natl Sch Engn Sfax ENIS Lab Enzyme Engn &

    Microbiol POB 1173 Sfax 3038 Tunisia;

    Univ Sfax Natl Sch Engn Sfax ENIS Lab Enzyme Engn &

    Microbiol POB 1173 Sfax 3038 Tunisia;

    Univ Sfax Natl Sch Engn Sfax ENIS Lab Enzyme Engn &

    Microbiol POB 1173 Sfax 3038 Tunisia;

    Ctr Reg Transfus Sanguine Sfax Route El Ain Km 0-5 CP 3003 Sfax Tunisia;

    Univ Sfax Fac Sci Sfax Lab Anim Ecophysiol POB 95 Sfax 3052 Tunisia;

    Ctr Reg Transfus Sanguine Sfax Route El Ain Km 0-5 CP 3003 Sfax Tunisia;

    Univ Oran Fac Sci Nat &

    Vie Lab Nutr Clin &

    Metab 1 Ahmed Ben Bella Oran Algeria;

    Univ Sfax Natl Sch Engn Sfax ENIS Lab Enzyme Engn &

    Microbiol POB 1173 Sfax 3038 Tunisia;

    Univ Sfax Natl Sch Engn Sfax ENIS Lab Enzyme Engn &

    Microbiol POB 1173 Sfax 3038 Tunisia;

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