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Bio-inspired microcapsule for targeted antithrombotic drug delivery

机译：生物启发微胶囊，用于靶向抗血栓药物递送

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摘要

Thrombosis or embolism is the leading cause of death and long-term adult disability worldwide. To reduce the risk of thrombosis and hemorrhaging in patients, a facile and versatile method was developed to fabricate microcapsules for targeted antithrombotic drug delivery. The microcapsules were prepared via oxidative polymerization of dopamine on polystyrene microspheres, followed by immobilization of fibrinogen onto the surface of poly(dopamine) layers. Subsequently, microcapsules were obtained by removing the cores with THF. Nattokinase was loaded into the microcapsules via diffusion. The loading amount was approximately 0.05 mg g(-1) at 37 degrees C, and the loading efficiency was nearly 75%, based on the initial concentration of nattokinase in PBS. The release of nattokinase was a gradual process at 37 degrees C, and the activity of the targeted activated platelets was highly efficient. The antithrombotic activity of the nattokinase microcapsules was evidenced by the sharp dissolution of fibrin clots and the blood clotting time indexes. A gradual release mechanism of platelet-inspired microcapsules used for targeted antithrombotic therapy was proposed. This strategy for targeted antithrombotic drug delivery, which lowers the demand dose and minimizes side effects while maximizing drug efficacy, provides a potential new way to treat life-threatening diseases caused by vascular disruption.
机译：血栓形成或栓塞是全世界死亡和长期成人残疾的主要原因。为了降低患者血栓形成和出血的风险，开发了一种容易和多功能的方法，用于制造针对靶向抗血栓药物递送的微胶囊。通过在聚苯乙烯微球上的多巴胺的氧化聚合制备微胶囊，然后将纤维蛋白原固定到聚（多巴胺）层的表面上。随后，通过用THF除去核来获得微胶囊。通过扩散将NattOkinase加载到微胶囊中。在37℃下，负载量为约0.05mg（-1），并且基于PBS中NattOkinase的初始浓度，负载效率接近75％。 NattOkinase的释放是在37℃的逐渐过程中，靶向活化血小板的活性高效。通过纤维蛋白凝块和血液凝结时间指标的尖锐溶解证明了Nattokinase微胶囊的抗血栓活性。提出了一种用于靶向抗血栓形成疗法的血小板启发微胶囊的逐渐释放机制。这种针对性抗血栓药物递送的策略降低了需求剂量并最大限度地减少副作用，同时最大限度地提高药物功效，提供了一种潜在的新方法来治疗血管破坏引起的危及生命疾病。

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  • 来源
    《RSC Advances》 |2018年第48期|共7页
  • 作者

    Ye Wei; Wang Nan; Hu Kebang; Zhang Lincai; Liu Aihui; Pan Changjiang; Gong Tao; Liu Tao; Ding Hongyan;

  • 作者单位

    Huaiyin Inst Technol Jiangsu Prov Key Lab Intervent Med Devices Huaian 223003 Peoples R China;

    Huaiyin Inst Technol Jiangsu Prov Key Lab Intervent Med Devices Huaian 223003 Peoples R China;

    Jilin Univ Hosp 1 Dept Urol Changchun 130021 Jilin Peoples R China;

    Huaiyin Inst Technol Jiangsu Prov Key Lab Intervent Med Devices Huaian 223003 Peoples R China;

    Huaiyin Inst Technol Jiangsu Prov Key Lab Intervent Med Devices Huaian 223003 Peoples R China;

    Huaiyin Inst Technol Jiangsu Prov Key Lab Intervent Med Devices Huaian 223003 Peoples R China;

    Huaiyin Inst Technol Jiangsu Prov Key Lab Intervent Med Devices Huaian 223003 Peoples R China;

    Huaiyin Inst Technol Jiangsu Prov Key Lab Intervent Med Devices Huaian 223003 Peoples R China;

    Huaiyin Inst Technol Jiangsu Prov Key Lab Intervent Med Devices Huaian 223003 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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