Enzymatic synthesis of 2-hydroxy-4H-quinolizin-4-one scaffolds by integrating coenzyme a ligases and a type III PKS fromHuperzia serrata

Wang Juan; Ding Ning; Wu Yun; Shi Xiaoping; Qi Bowen; Liu Xiao; Wang Xiaohui; Li Jun; Tu Pengfei; Shi Shepo

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Enzymatic synthesis of 2-hydroxy-4H-quinolizin-4-one scaffolds by integrating coenzyme a ligases and a type III PKS fromHuperzia serrata

机译：通过将辅酶与肝硬化的辅酶与肝脏和III PKS相结合来酶合成2-羟基-4H-喹啉-4-单支架

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2-Hydroxy-4H-quinolizin-4-one scaffolds were enzymatically synthesized by integrating three enzymes including phenylacetate-CoA ligase (PcPCL) from an endophytic fungusPenicillium chrysogenumMT-12, malonyl-CoA synthase (AtMatB) fromArabidopsis thaliana, and a type III polyketide synthase (HsPKS3) from Chinese club mossHuperzia serrata. The findings paved the way to produce these kinds of structurally interesting alkaloids by engineered microorganisms.

机译：通过将包括苯乙酸酯-COA连接酶（PCPCL）的三种酶与内生真菌甲醇植物生成-12，丙氨酸 - COA合酶（ATMATB）从偏离氨基吡咯和III型聚丙烯酯（PCPCl）与III型聚丙烯酯（PCPCL）与苯乙酸酯-CoA结扎酶（PCPCl）的酶合成酶促合成2-羟基-4H-喹啉嗪-4-一支支架。来自中国俱乐部Mosshuperzia Serrata的合成酶（HSPKS3）。调查结果铺平了通过工程化微生物生产这些结构有趣的生物碱的方法。

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来源
《RSC Advances》 |2020年第40期|共7页
作者
Wang Juan; Ding Ning; Wu Yun; Shi Xiaoping; Qi Bowen; Liu Xiao; Wang Xiaohui; Li Jun; Tu Pengfei; Shi Shepo;
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Beijing Univ Chinese Med Modern Res Ctr Tradit Chinese Med Beijing 100029 Peoples R China;

Beijing Univ Chinese Med Modern Res Ctr Tradit Chinese Med Beijing 100029 Peoples R China;

Beijing Univ Chinese Med Modern Res Ctr Tradit Chinese Med Beijing 100029 Peoples R China;

Beijing Univ Chinese Med Modern Res Ctr Tradit Chinese Med Beijing 100029 Peoples R China;

Beijing Univ Chinese Med Modern Res Ctr Tradit Chinese Med Beijing 100029 Peoples R China;

Beijing Univ Chinese Med Modern Res Ctr Tradit Chinese Med Beijing 100029 Peoples R China;

Beijing Univ Chinese Med Modern Res Ctr Tradit Chinese Med Beijing 100029 Peoples R China;

Beijing Univ Chinese Med Modern Res Ctr Tradit Chinese Med Beijing 100029 Peoples R China;

Beijing Univ Chinese Med Modern Res Ctr Tradit Chinese Med Beijing 100029 Peoples R China;

Beijing Univ Chinese Med Modern Res Ctr Tradit Chinese Med Beijing 100029 Peoples R China;

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正文语种 eng
中图分类化学;
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1. Enzymatic synthesis of 2-hydroxy-4H-quinolizin-4-one scaffolds by integrating coenzyme a ligases and a type III PKS fromHuperzia serrata [J] . Wang Juan, Ding Ning, Wu Yun, RSC Advances . 2020,第40期

机译：通过将辅酶与肝硬化的辅酶与肝脏和III PKS相结合来酶合成2-羟基-4H-喹啉-4-单支架
2. Enzymatic Synthesis of 1,3,6,8-Tetrahydroxynaphthalene Solely form malonyl Coenzyme A by a Fungal Iterative Type I Polyketide Synthase PKS1 [J] . Fujii Isao, Mori Yuichiro, Watanabe Akira, Biochemistry . 2000,第30期

机译：真菌迭代I型聚酮化合物合酶PKS1酶促合成1,3,6,8-四羟基萘单形式的丙二酰辅酶A
3. Enzymatic Synthesis of 1,3,6,8-Tetrahydroxynaphthalene Solely from Malonyl Coenzyme A by a Fungal Iterative Type I Polyketide Synthase PKS1 [J] . Fujii Isao Biochemistry . 2000,第30期

机译：真菌迭代I型聚酮化合物合酶PKS1从丙二酸辅酶A酶促合成1,3,6,8-四羟基萘
4. TYPE SYNTHESIS PRINCIPLE AND PRACTICE OF FLEXURE SYSTEMS IN THE FRAMEWORK OF SCREW THEORY PART III: NUMERATIONS AND TYPE SYNTHESIS OF FLEXURE MECHANISMS [C] . S. Z. Li, J. J. Yu, X. Pei, International Design Engineering Technical Conferences . 2010

机译：螺杆理论框架框架型合成原理与弯曲系统的实践第三部分：挠性机制的数值和型合成
5. Structural studies of: PAM (phenylalanine aminomutase), and BadA (benzoate coenzyme A ligase); Purification and crystallization trials of: mSNAPc (small nuclear RNA activating protein), and TF8 (TFIIIB BRF1-TBP triple fusion) [D] . Strom, Susan Marie 2012

机译：结构研究：PAM（苯丙氨酸氨基变位酶）和BadA（苯甲酸酯辅酶A连接酶）；纯化和结晶试验：mSNAPc（小核RNA活化蛋白）和TF8（TFIIIB BRF1-TBP三重融合）
6. Chemoenzymatic Synthesis and Biological Evaluation for Bioactive Molecules Derived from Bacterial Benzoyl Coenzyme A Ligase and Plant Type III Polyketide Synthase [O] . Kamal Adhikari, I-Wen Lo, Chun-Liang Chen, 2020

机译：细菌苯甲酰辅酶A连接酶和植物III型聚酮化合物合酶衍生的生物活性分子的化学合成及生物学评价
7. Enzymatic synthesis of 2-hydroxy-4H-quinolizin-4-one scaffolds by integrating coenzyme a ligases and a type III PKS from Huperzia serrata [O] . Juan Wang, Ning Ding, Yun Wu, 2020

机译：通过将辅酶酶与Huperzia serrata集成的辅酶和III PKS将酶合成2-羟基-4H-喹啉-4-一支支架的酶促合成
8. Enzymatic Synthesis of Citric Acid. 5. Reaction of Acetyl Coenzyme A. [R] . Stern, J. R., Ochoa, S., Lynen, F. 1952

机译：酶法合成柠檬酸。 5.乙酰辅酶a的反应。

Enzymatic synthesis of 2-hydroxy-4H-quinolizin-4-one scaffolds by integrating coenzyme a ligases and a type III PKS fromHuperzia serrata

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