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Amphiphilic poly(caprolactone-b-N-hydroxyethyl acrylamide) micelles for controlled drug delivery

机译：两亲多（己内酯-B-N-羟乙基丙烯酰胺）用于受控药物递送的胶束

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摘要

To increase the bioavailability and water solubility of hydrophobic medicine, an amphiphilic block copolymer, polycaprolactone-block-polyhydroxyethyl acrylamide (PCL-b-PHEAA), was synthesized. The copolymer can self-assemble into micelles by dialysis. The micelles were characterized by the Tyndall effect, static drop method, fluorescence spectrometry, dynamic light scattering, scanning electron microscopy and transmission electron microscopy. Ibuprofen was encapsulated inside the micelles by dialysis as a model medicine. The results show that the amphiphilic copolymer forms a uniform micelle system, with spherical micelles dispersed well in solution which have a low critical micelle concentration. In addition, the system shows good amphipathic behavior. Average particle size of a micelle is 104 nm, which increases a lot after drug loading and standing for half a month. In the first few hours, the cumulative release of the drug increases gradually; the rate of increase in the first ten hours is faster, then reaching a plateau which tends to be flat finally. It is similar under two different pH conditions. This biocompatible, biodegradable amphiphilic block copolymer has potential applications in the biomedical field.
机译：为了提高疏水性药物的生物利用度和水溶性，合成两亲嵌段共聚物，聚己内酯 - 嵌段 - 多羟基乙基丙烯酰胺（PCL-B-PHEAA）。共聚物可以通过透析自组装成胶束。胶束的特征在于Tyndall效应，静电方法，荧光光谱法，动态光散射，扫描电子显微镜和透射电子显微镜。将布洛芬通过透析作为模范药物封装在胶束内。结果表明，两亲共聚物形成均匀的胶束系统，用球形胶束分散在具有低临界胶束浓度的溶液中。此外，该系统显示出良好的两亲性行为。胶束的平均粒径为104nm，药物载荷后增加了大量的粒度，占地半月。在最初的几个小时内，药物的累积释放逐渐增加;前十个小时的增加率更快，然后达到最终趋于平坦的平台。它在两个不同的pH条件下类似。这种生物相容性的可生物降解的两亲嵌段共聚物具有在生物医学领域的潜在应用。

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  • 来源
    《RSC Advances》 |2020年第50期|共7页
  • 作者

    Wu Shuangxia; Geng Fengjie; He Suqin; Liu Wentao; Liu Hao; Huang Miaoming; Zhu Chengshen;

  • 作者单位

    Zhengzhou Univ Sch Mat Sci &

    Engn Zhengzhou 450001 Henan Peoples R China;

    Zhengzhou Univ Sch Mat Sci &

    Engn Zhengzhou 450001 Henan Peoples R China;

    Zhengzhou Univ Sch Mat Sci &

    Engn Zhengzhou 450001 Henan Peoples R China;

    Zhengzhou Univ Sch Mat Sci &

    Engn Zhengzhou 450001 Henan Peoples R China;

    Zhengzhou Univ Sch Mat Sci &

    Engn Zhengzhou 450001 Henan Peoples R China;

    Zhengzhou Univ Sch Mat Sci &

    Engn Zhengzhou 450001 Henan Peoples R China;

    Zhengzhou Univ Sch Mat Sci &

    Engn Zhengzhou 450001 Henan Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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