• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Sinapine-enriched rapeseed oils reduced fatty liver formation in high-fat diet-fed C57BL/6J mice
【24h】

Sinapine-enriched rapeseed oils reduced fatty liver formation in high-fat diet-fed C57BL/6J mice

机译：富含辛滨的菜籽油减少了高脂饮食喂养C57BL / 6J小鼠脂肪肝形成

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Oil enrichment with trace amounts of components has significant effects on animal nutrition and health. In this work, the potential impact of sinapine, a trace amount of polyphenol naturally present in rapeseeds, was investigated in high-fat diet (HF)-fed C57BL/6J mice. The mice were fed with different diets including chow diet (LF), HF diet, rapeseed oil-containing HF diet (RO), and rapeseed oils enriched with sinapine (500 mg kg(-1)oil, high-fat diet, RP) for 12 weeks. Here, it was demonstrated that sinapine supplementation significantly reduced (P< 0.05) body weight increase, fat accumulation, and fatty liver formation in mice when compared with those fed with a high-fat diet. The TG, LDL-C, ALT and AST levels in the RP group were significantly reduced (P< 0.05) by 15.67%, 73.62%, 20.67%, and 31.58%, respectively, compared with that in the HF group. Besides, the addition of sinapine prevented the degeneration of mouse adipocytes and lipid accumulation in the liver. Moreover, this change was achieved by downregulating SREBP-1c and FAS and upregulating PPAR-alpha and ACOX1 gene expression levels. Our results indicate that sinapine can be used as a prebiotic to enhance the nutritional function of vegetable oils to prevent obesity-related chronic diseases such as NAFLD.
机译：具有痕量组分的石油富集对动物营养和健康具有显着影响。在这项工作中，在高脂饮食（HF）-FED的C57BL / 6J小鼠中研究了Sinapine的潜在影响，这是一种天然存在于菜籽中的多酚。用不同的饮食喂食小鼠，包括Chow Diet（LF），HF饮食，含菜籽油的含油HF饮食（RO），以及富含锡鞘的菜籽油（500毫克KG（-1）油，高脂饮食，RP） 12周。在这里，与用高脂饮食的人相比，表明鼻腔补充剂显着降低（P <0.05）体重增加，脂肪累积和脂肪肝形成。与HF组中，RP组中的Tg，LDL-C，ALT和AST和AST水平显着降低（P <0.05），分别显着降低（P <0.05），分别为15.67％，73.62％，21.58％。此外，添加鼻窦预防小鼠脂肪细胞和肝脏脂质积累的退化。此外，通过下调Srebp-1c和Fas和上调PPAR-α和ACOX1基因表达水平来实现这种改变。我们的研究结果表明，锡滨可用作益生元，以增强植物油的营养功能，以防止肥胖相关的慢性疾病如NAFLD。

著录项

  • 来源
    《RSC Advances》 |2020年第36期|共11页
  • 作者

    Li Youdong; Li Jinwei; Cao Peirang; Liu Yuanfa;

  • 作者单位

    Jiangnan Univ Sch Food Sci &

    Technol 1800 Lihu Rd Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Sch Food Sci &

    Technol 1800 Lihu Rd Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Sch Food Sci &

    Technol 1800 Lihu Rd Wuxi 214122 Jiangsu Peoples R China;

    Jiangnan Univ Sch Food Sci &

    Technol 1800 Lihu Rd Wuxi 214122 Jiangsu Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号